人脑如此复杂的性状的进化，绝非单个基因或单个调控机制所致，唯有综合归纳多层面各种元件和遗传调控机制，才有可能有望取得突破进展。因而探索人类大脑快速进化的遗传机制需要挖掘更多的相关基因和新的调控机制。lincRNA基因在神经系统中的重要性为研究人类大脑进化的遗传机制提供新的视角，然而年轻新起源的lincRNA基因在人类大脑进化中的作用至今还未得到系统性的研究。本项目将解析出人类年轻新起源的lincRNA基因，整合生物信息学、系统生物学、神经生物学方法，研究年轻新起源lincRNA基因的进化特征和功能特征， 明确2-3个新起源lincRNA基因在人类神经系统中的作用机制， 探索人类大脑快速进化的遗传机制, 为揭示人类大脑功能演化的遗传学机制提供新的思路和基础数据。

Evolution of human complex brain can not be attributable to single gene or single regulatory mechanism. Only synthesize the various elements and multidimensional genetic regulatory mechanism is expected to be possible to achieve breakthroughs. Thus explore the genetic mechanisms underlying rapid evolution of the human brain need to tap more relevant genes and new regulatory mechanisms. The importance of lincRNA genes in the nervous system provides a new perspective for the study of genetic mechanisms of the human brain. However, the role of the young new lincRNA genes originated in the evolution of the human brain has not been systematically studied. The project will parse out the young originated human lincRNA genes and study their evolutionary and functional characteristics by integrating bioinformatics, systems biology, and neurobiology methods, and find out the functional mechanism of 2-3 young originated lincRNA in the human nervous system. It will help to explore the genetic mechanisms of rapid evolution the human brain, providing new ideas and basic data for studying the genetic mechanisms of rapid evolution the human brain。