脊椎动物的基因组中包含多种病毒序列，这些序列统一称为内源病毒元件。关于内源病毒的研究多集中于哺乳动物，然而因为缺乏数量可观的鸟类基因组供研究，人们对鸟类内源病毒元件知之甚少。我们之前的研究发现嗜肝DNA病毒及逆转录病毒的内生作用贯穿于整个鸟类系统发生历史。本项目拟对我们新测得的250条鸟类的基因组中的嗜肝DNA病毒及逆转录病毒来源的内源病毒进行分析，并结合一系列的生物信息学的手段，例如比较基因组学、系统发生学以及转录组学，清晰地构建两种内源病毒的整合位点图谱，并且探寻病毒插入鸟类基因组后对宿主基因组的重塑造成的影响。本研究将揭示在长达1亿年的进化历史中，由内源病毒介导的鸟类基因组动力学特征。

Vertebrate genomes contain numerous viral sequences termed as endogenous viral elements in general. Previous studies of endogenous viruses focused on mammals; however, due to lack of comparable genomes for birds, far less is known about endogenous viral elements in avian species. We have revealed that hepadnaviruses and retroviruses commonly infiltrated in avian phylogeny. In this study, we aim to analyze the endogenous hepadnaviral and retroviral elements in newly sequenced 250 avian species and a series of bioinformatics techniques will be conducted including comparative genomics, phylogenetics and transcriptomic analysis, in order to construct a clear integration map of the two endogenous viruses and decipher the effect of genomic rearrangement by viral integration. Our study is to uncover the avian genomic dynamics via endogenous viruses during 100 million years history of birds.