申请人工作聚焦于分子影像和功能影像学领域，研究糖尿病血管内皮功能紊乱、脂肪代谢紊乱的发生发展机制，筛选影像标志物，发展了糖尿病微循环障碍的早期检测和干预方法。建立了内皮祖细胞（EPCs）体内示踪的多模态成像方法，动态揭示了细胞移植后存活增殖分化特点。发现糖尿病基础状态下细胞移植联合p38 MAPK通路抑制的再生修复调节新机制，提出了对糖尿病并发症EPCs移植治疗新策略。上述研究不仅为糖尿病多器官并发症诊疗提供了关键靶点和成像方法，也推动了细胞治疗机制的在体研究。主持国家自然科学基金重点项目等6项基金，近5年发表SCI论文35篇，其中第一/通讯作者17篇，包括ACS Nanao、Biomaterials、Radiology，相关工作被Chemical Reviews正面报道，Radiology述评予以高度评价，获教育部科技进步一等奖、教育部新世纪优秀人才支持计划。

The applicant has been engaged in the multidisciplinary research on molecular and functional imaging. Focusing on studying the mechanism of diabetes-induced lipid metabolism disorder and vascular endothelial dysfunction, the applicant has screened and explored the novel imaging biomarkers, which leads to the development of early detection and intervention of diabetes. The studies have innovatively established a series of multi-modality imaging methods to visualize transplanted endothelial progenitor cells (EPCs) in vivo, and revealed dynamically the characteristics of cells survival, proliferation and differentiation after cells transplantation. Moreover, the applicant revealed a novel regulatory mechanism that combining cells transplantation and p38 MAPK pathway inhibitor can promote regenerative repair under fundamental diabetes state, and novelly reported a new therapeutic strategy that treating diabetic complications with EPCs transplantation. These studies not only contribute to the development of key targets and molecular imaging strategies on diabetic multi-organ complications, but also hold great promise to promote the mechanism research of cell therapy in vivo. The applicant is PI in 6 national grants including National Natural Science Foundation Major Program, published 35 papers in past five years, 17 papers as first and/or corresponding author including ACS NANO, BIOMATERIALS and RADIOLOGY. Research results are positively cited and reported by well-known scientific journals, like CHEMICALREVIEWS, written in books including ‘Emerging Trends in Cell and Gene Therapy’. The journal of RADIOLOGY published a well-known expert’s commentary to our paper, titled as ‘new insights with functional MR imaging’. The applicant also won the first Prize of ‘of Ministry of Education Science and Technology Progress Award’ and ‘Program for New Century Excellent Talents in University’.