前六年团队聚焦传染性病原微生物（尤其是流感病毒，埃博拉病毒，肝炎病毒等）与宿主的相互作用，在病毒的溯源、跨种传播和入侵机制等方面取得重要突破，形成了一支在国际国内具有重要影响力的研究团队。本项目将在前期工作的基础上，持续开展以流感为代表的动物源性病毒溯源与跨种传播机制研究，为我国新生、突发传染病的防控提供理论基础；深入研究受体及宿主因子与病毒的相互作用，揭示病毒的入侵机制及复制与感染的调控机制，寻找抗病毒新靶点；进一步研究抗病毒天然免疫的调控机制，系统阐明病毒抗原呈递与细胞免疫调控分子机理；筛选针对不同病原的人源治疗性抗体及小分子化合物，为设计新型抗病毒药物和疫苗提供依据。

Our group has mainly focused on the interaction between infectious viral pathogens(including influenza virus, Ebola virus, Hepatitis B virus, etc) and host in the last 6 years. We have made significant contributions to the field of virus origin, mechanisms of interspecies transmission and virus entry. In this project, we will continue to study the origins and host-jump mechanisms of emerging zoonotic viruses, virus entry and release, the interaction between the viruses (such as influenza virus and hepatitis B virus) and host factors, and regulation mechanisms of anti-viral innate immunity. We will also screen therapeutic human antibodies and small molecule chemicals against different pathogens, providing structure-based rationales for the design of effective drugs and vaccines.