申请人长期工作在胸外科临床一线，在创新技术，支气管扩张治疗与研究，和肺癌复发转移治疗与研究三个方面进行了积极探索。多项发明专利应用于临床。申请人发现支气管扩张患者存在SCAP分子的低表达，深入的阐述了胞内病原体识别信号通路中SCAP发挥的关键作用，为理解支气管扩张的发病机理提供了新的视角，研究成果发表在PLoS Pathog（IF=7.6）。申请人证实非小细胞肺癌术后复发转移的高危分子生物学因素，并建立了肺癌-正常混合组织以及肺癌多亚群落组织甲基化组的概率模型。研究成果发表在Genome Biol（IF=10.5），Sci Rep（IF=5.6，2篇）。本课题拟通过临床样本和小鼠模型进行肺切除术后代偿性生长的临床基础研究，探讨巨噬细胞与内皮细胞的交互作用在代偿性肺生长中的作用机制，丰富肺代偿性生长的新理论，为临床应用提供新思路。

The applicant has been working in the field of thoracic surgery, exhibiting outstanding surgical skills. He has had good experience in lung and trachea transplantation and in the minimally invasive treatment of chest diseases. He is capable of performing uniportral Video-assisted Thoracic Surgery . Moreover, He has completed a series of innovation in the thoracic surgery technology with several patents.He has been actively engaged in studying the mechanism of in angiogenesis and surgical treatment of bronchiectasis, and has gained a lot of achievements during the last 5 years. Collaborating with team members, Dr. Zhang et al. identified several high-risk factors for the recurrence and metastasis of the non-small cell lung cancer. Their work has been published in top journals in thoracic surgery, including Ann Thorac Surg(IF=3.9), Sci Rep (IF = 5.6), Plos Pathog（IF=7.6）,as well as Genome Biol (IF = 10.5). The goal of this project intends to study the compensatory growth of remaining lung tissue post-lung resection surgery. Through the clinical cases and mouse models, Dr. Zhang’s team are going to explore the mechanism of interaction between macrophages and endothelial cells the compensatory lung growth and angiogenesis. Such study will deepen the understanding of compensatory lung growth.