“功效”是对中药作用的特殊表述，开展基于功效的中药复方物质基础研究，有助于阐释中药复方功效的科学内涵，对于中药的国际化、现代化具有重大意义。通过分析制约中药复方物质基础研究的主要因素，结合前期工作基础，提出工作假说：功效代表了中药复方的整体效应，该效应是多种化学成分在特定病证状态下对机体的作用。分析整合病证的生物学基础、药效指标和成分三者的对应关系，即有可能阐释中药复方的功效物质基础。 .为论证上述假设，本课题选用有良好工作基础的有效中药复方祛瘀化痰通脉方，从基础和临床两个方面开展痰瘀互结证的代谢组学研究，从中寻找相同或相近的生物标志物和代谢途径，并以此为指导开展复方中“祛瘀”、“化痰”和“解毒”不同功效的生物学基础和药理学研究，阐释生物标志物和有效药理指标的内在联系。在此基础上进行药代动力学-生物标志物-药效动力学的联动分析，明确复方功效物质基础，最终建立符合中医特点的现代研究模式。

Research on the efficacy material base of Chinese herb prescription help to explain the scientific content of traditional Chinese medicine(TCM) effect, which means a lot to modernization and internationalization of TCM. In this project, we put forward the scientific hypothesis by analyzing the main factors restrict to the research of efficacy material base and combining the previsous work. Efficacy material base of Chinese herb prescription represent its whole effect, which happened under a certain "Zheng" condition by many chemical constituents. Analyzing and integrating the biological basis, pharmacodynamics index and chemical constituets of syndrome in TCM ,might explained the efficacy material base of Chinese herb prescription..Based on the assumptions above, Quyu Huatan Tongmai Formula which has a good foundation are selected to study. To investigae the identical or similar biomarkers and matabolic pathways, the metabonomics was applicated to phlegm and stasis syndrome of animal and patient.Guided by the results above,the biological basis and pharmacological study of removing blood stasis, reduce phlegm and detoxification will carry out. Dynamic analysis of the pharmacokinetics-biomarkerdynamics-pharmacodynamics data will carry out to find the efficacy material base of Chinese Herb Prescription and to bilud a modern research model of TCM efficacy finally.