新疆有丰富的野生火绒草资源，但对其资源、有效成分和药理作用尚缺乏深入系统的研究。本项目沿天山山脉和阿勒泰山脉选点，进行火绒草资源调查，包括采集标本，考察其分布和储量，测定生长地的地理环境参数。通过移地栽培和繁殖，比较野生和种植火绒草中的成分和有效成分含量，建立完善火绒草资源保护和可持续性利用技术体系。以火绒草中降血糖成分为导向，利用药物致糖尿病小鼠模型筛选降血糖活性成分。通过测定糖尿病小鼠肝脏糖代谢的4种关键酶和小肠中水解多糖的2种酶活性，明确降血糖活性成分对酶的抑制或激活作用，进一步在体外验证降血糖成分与酶作用及生理生化性质。通过正、反相硅胶柱层析、葡聚糖凝胶LH-20柱层析和制备型高效液相色谱分离纯化降血糖有效成分，进行纯度鉴定，结构测定。这项研究对于开发火绒草天然降血糖成分具有重要的科学价值和应用前景。

Xinjiang has rich resources of wild Leontopodium leontopodioides. However, systematic research on its resources, useful components and pharmacological effectiveness is scanty. This project investigates the locational distribution and recoverable reserves of Leontopodium leontopodioides along the Tianshan mountains and Aletai mountains, by collecting samples and gauging environmental parameters of its habitatation, cultivation and reproduction. We make comparisons of its ingredients and effective components between the wild Leontopodium leontopodioides and the cultured counterparts. The hypoglycemic constituents in Leontopodium leontopodioides will be screened using the medicine induced diabetes mouse model. In orde to ascertain activation and inhibition effects of the hypoglycemic components on enzymes, we examine four different kinds of glucose metabolic enzymes from the diabetic mouse liver and two kinds of hydrolyzed polysaccharide enzymes from the mouse small intestine, respectively. Furthermore，we observe interactions between hypoglycemic component and the enzymes. Their physiological and biochemical properties will be determined in vitro. The hypoglycemic constituents will be separated and purified by column chromatography of positive and reverse phase silica gel, sephadex LH-20, and high performance liquid chromatography. We then determine its purity and structure. The study will provide some science data and the application value on development of the natural hypoglycemic constituents from Leontopodium leontopodioides.