寄生性线虫种类多、分布广，是我国北方草原地区严重危害畜牧业发展的家畜疫病，传统的化学药物防治法所导致的食品安全问题不仅对消费者健康构成了严重威胁，而且成为我国动物性食品进入国际市场的"绿色贸易壁垒"。解决这一问题的最佳源头控制方法是研究开发生物天敌，对其进行生物控制。本项目拟在前期研究工作的基础上，对捕食性真菌Duddingtonia flagrans含捕食器菌丝和普通营养菌丝（不含捕食器）进行转录组和蛋白质组学研究，探索含捕食器菌丝和普通营养菌丝（不含捕食器）在代谢水平上的差异，发掘捕食器基因及捕食相关基因，并进行功能研究和鉴定，为探讨捕食性真菌捕食器的形成机制及捕食线虫的分子机制研究提供重要资料，也为开发对线虫等寄生虫有毒性的生物制剂和利用基因工程技术改造捕食性真菌奠定基础。其成果不仅可以填补相关研究领域的空白，也为更好地在生产实际中利用捕食性真菌这类生物天敌资源提供科学依据。

Parasitic nematodes, for their multispecies and wide distribution, had brought serious damage to the development of animal husbandry in China's northern grassland. The use of nematicides has become increasingly restricted duce to anthelmintic resistance, public health and environmental concerns. To get rid of these problems, control by the nematode-trapping fungus has attracted much attentions. On the basis of finished studies before, this program will analyze the transcriptome and proteome of the nematode-trapping fungi- Duddingtonia flagrans, respectively. Then the differences in the metabolism of hyphae with organs and general vegetative hyphae ( without organs ) were also studied. Simultaneously, gene of organs and some nematode-trapping related genes were screened, and followed by verifying their functions preliminarily. So it would provide important information to investigate the mechanisms of the molecular mechanisms of organs formation and the trapping to nematodes. Besides, it would also settle foundation for development of secretions or toxic biologicals of the nematodes and the use of genetic engineering transformation to nematode-trapping fungi. The program would enrich the knowledge of the relevant field, and provide a scientific basis for better use of nematode-trapping fungi in the practical production.