我国重症中暑合并MODS死亡率高达35％。课题组所在单位2011年提出中暑“第二关键点”理论，即在降温基础上，对炎症引起的SIRS和MODS进行防治是治疗的“第二关键点”。并在前期研究中发现：1）SIRS和MODS发生的始动器官——肠道在中暑时损伤明显、屏障功能减弱；2）多种炎症介质如IL-1β和TNF-α等在此过程中变化显著；3）初步筛选出具有代表性的分子：HMGB1、occludin、ZO-1和FBP。既往研究发现：血必净注射液具有拮抗内毒素，抑制炎症等作用。课题组近期临床观察也发现，应用血必净可显著降低重症中暑患者死亡率；予中暑大鼠血必净治疗能明显缓解肝脏损伤程度，抑制枯否细胞分泌功能。然而，血必净在中暑时的肠道保护作用和机制尚未见报道。因此，本研究拟进一步以热打击动物、肠道细胞模型和临床患者为研究对象，全面分析血必净在中暑过程中的肠道保护作用及机制，为血必净的临床应用奠定理论基础。

In China, the mortality of severe heatstroke with MODS was up to 35%. The research group proposed the "second critical point" theory in 2011--based on the cooling, the preventions and treatments of inflammation induced by SIRS and MODS were the second critical point for treatments of severe heatstroke. In the previous study, we have found that: 1, The initiating organ of SIRS and MODS--injury of intestinal during heatstroke was significant, and the barrier function was also weakened; 2, various inflammatory mediators in this process varied significantly, such as IL-1β, TNF-αet al; 3, representative molecules were preliminary screened: HMGB1,occludin,ZO-1and FBP. Previous studies found that: Xuebijing injection had effects of endotoxin antagonisting, inflammation inhibiting, et al. Our recent clinical observation also found that, Xuebijing can significantly reduce mortality in patients with severe heatstroke; Xuebijing can significantly alleviate the degree of liver damage and inhibit secretory function of KUFF cells in rats with heatstroke. But, during heatstroke process, the protective effects and mechanisms of Xuebijing in gut has not been reported. In this study, we observed animals with heatstroke, intestinal cell model and clinical patients, and comprehensively analyzed the protective effects and mechanisms of Xuebijing in gut during heatstroke process, this would be the theoretical basis for clinical application of Xuebijing.