随着干细胞治疗心肌梗死（AMI）研究深入，已经认识到AMI后形成的缺血缺氧微环境是导致间充质干细胞（BMSCs）生存率低主要原因。微环境是干细胞发育的土壤，在干细胞存活、增殖分化中扮演着重要作用。中医药通过体内用药能纠正阴阳失调的机体内环境，也应该能改善梗死区缺血缺氧微环境，使之成为更适合干细胞生存的微环境。这无疑是中医药干预AMI后心肌重塑新思路。.拟在国家自然基金（81072798／H2708）活血化瘀法动员BMSCs防治心梗后心肌重塑研究基础上，以名老中医经验方-补肾化瘀生新方为干预手段，利用心肌缺血缺氧微环境模型和miRNA微阵列等技术，研究其对miRNAs表达、BMSCs存活率以及对静脉移植BMSCs在心梗区分化率的影响，揭示补肾化瘀生新方改良梗死区微环境提高BMSCs存活率和分化率防治心梗后心肌重塑机制，阐明中医药提高BMSCs存活率和分化率科学性，为心肌重塑的防治提供新模式。

With the deepening of researches into the treatment of acute myocardialinfarction (AMI) with stem cells, people realize that the ischemic-hypoxia microenvironment formed after AMI is the major cause of the low survival rate of bone mesenchymal stem cells (BMSCs). The microenvironment, as the soil of stem cells’ growth, plays an important role in the survival and proliferation. Traditional Chinese medicine can correct the imbalance of yin and yang in the internal environment, improve the ischemic-hypoxia microenvironment after AMI, making it more suitable microenvironment for the survival of stem cells. This is undoubtedly a new idea that TCM interferes myocardial remodeling after AMI..On the basis of the study of myocardial remodeling after the treatment of AMI with the method of promoting blood circulation to remove blood stasis and mobilizing BMSCs under the support of the National Natural Science Foundation（81072798／H2708), using Bushen Huayu Shengxin Decoction as intervention means and the models of myocardial ischemic-hypoxia microenvironment and MicroRNA (miRNA) microarray technology, the author explored the influence of Bushen Huayu Shengxin Decoction on the miRNAsexpression, survival rate of BMSCs and the survival and transdifferentiation rate of transplanted BMSCs after AMI. The study reveals that Bushen Huayu Shengxin Decoction can improve the micro-environment of the myocardial infarction area, increase BMSCs’survival rate and improve the myocardial remodeling after the treatment of AMI, which reveals the scientific nature of traditional Chinese medicine in improving the survival rate and differentiation rate of BMSCs，and provide a new pattern for the prevention and treatment of myocardial remodeling.