本申请项目在继承超声稳态空化促进药物靶向递送、基因转染等对肿瘤治疗研究成果的基础上，拟建立一套基于超常结构透镜的低频低强度聚焦超声空化介导液汽相变微泡肿瘤治疗系统，利用低频超声的穿透能力强、空化阈值低的优势，对肿瘤组织进行杀伤；利用耦合了声学超常透镜结构的聚焦超声换能器，有效规避肋骨等障碍物对超声的散射/反射效应，解决低频超声换能器透声窗选择受限难题，减少其对声传播路径的影响，避免聚焦超声焦点偏移；采用液汽相变纳米微泡能穿透肿瘤血管内皮间隙进入肿瘤组织间质的性能，结合聚焦超声焦点温度调控解决低频超声谐振空化核粒径需求，可同时在肿瘤组织间质内和肿瘤血管内产生空化效应，以加强空化效应对肿瘤细胞的直接损伤；利用诊断B超系统实现靶区微泡空化效应的实时精确监控。为今后肿瘤超声空化治疗的科学研究提供安全、可行和有效的实验样机。

This project intends to carry on the succession of ultrasound cavitation promote targeted drug delivery, gene transfection, and cancer treatment, establish a low a low frequency low intensity focused ultrasound mediated microbubble liquid-vapor phase change cavitation tumor treatment system based on exceptional structure, using low frequency ultrasound penetration ability and low cavitation threshold to destroy cancer tissue. A low intensity focused ultrasound transducer coupling acoustic exceptional structure effectively avoid obstacles such as ribs, ultrasound scatter/reflection effect, solve the low frequency ultrasound transducer acoustic window selection problems, reducing its impact on the sound propagation path, avoid focus ultrasound focal point shift. Liquid-vapor phase change nanoscale microbubble can penetrate the tumor endothelial gap junction into tumor tissue, combining focused ultrasound focal point temperature control to solve the low frequency ultrasound resonant cavitation nuclear diameter demand, simultaneously generate cavitation in the tumor tissue and tumor blood vessels, strengthen the cavitation damage directly to tumor cells, and use diagnostic ultrasound system to accurate monitor realtime targeted microbubble cavitation, which may promote and facilitate translational and clinical medical research of ultrasound mediated microbubble cavitation tumor treatment.