申请人主要从事心肌细胞肥大，凋亡及坏死等心血管疾病分子机制研究。首次阐明了lncRNA通过海绵作用吸附miRNA来调节心肌肥大及凋亡的分子机理以及非编码RNA调控的线粒体分裂在心脏疾病中的作用。发现和揭示了参与心脏病理生理调节的新的信号通路和治疗的靶分子。相关研究成果发表在Circulation Research、Nature communications、Nature Medicine、Gene & Development、PNAS等杂志上。近年发表论文20余篇，引用次数494次。也已共同通讯作者在本领域发表文章两篇及获得六项发明专利。本项目计划在前期研究工作基础上进一步深入研究非编码RNA调控心肌凋亡及坏死的分子机制，解析心血管疾病的发生发展机制的分子基础。此项研究对于丰富和完善心脏分子和细胞生物学具有重要的理论意义,同时为探究心肌梗死及心衰的预防和治疗开辟一个新的方向。

The applicant mainly interests in studying the molecular mechanism of cardiovascular diseases, including cardiac hypertrophy, cardiomyocyte apoptosis and cardiomyocyte necrosis. Our work for the first time demonstrated that lncRNAs participated in regulating cardiac hypertrophy and apoptosis by sponging miRNA. And we identified the function of many non-coding RNAs in regulating mitochondrial fission and in cardiac diseases. Also, we unveiled several de novo signal pathways that regulated the pathological or physiological processes in cardiomyocytes. Research results have been published in Circulation Research, Nature communications, Nature Medicine, Gene & Development, PNAS, et al. In all, the applicant has 20 publications in recent years which have been cited for 494 times. Also, the applicant has published two scientific articles as a corresponding author and has obtained 6 Chinese patents for inventions. On the basis of previous discoveries, the proposed project plans to further study the function of non-coding RNA in cardiomyocyte apoptosis and necrosis and explores the molecular mechanisms of cardiovascular diseases. This project not only can add incremental knowledge for cardiac molecular and cellular mechanisms but also may provide effective therapy for myocardial infarction and heart failure.