申请人长期从事精子主要蛋白为基础的细胞运动与细胞迁移，以及调控精子细胞发育、成熟与精子竞争的分子机理。主要成绩如下:发现了精子成熟与精子竞争偶联的分子机制(PNAS, 2012);在秀丽线虫中发现了依赖于SPE-8信号通路的精子活化途径及信号转导机制(Development, 2013，BBA，2013)；(3)以胆固醇为主要构成的脂筏微结构域参与精子活化的信号转导，揭示了胆固醇在线虫和哺乳动物精子形成过程中具有功能保守性(BBA, 2012)；(4)系统研究了线虫精子发生的转录调控机制(BMC Genomics, 2011, 2014); 作为主要合作者与国内同行合作发表论文3篇(Cell, 2009；Science, 2010； PLoS Genetics, 2013)。2009年来以通讯作者发表SCI文章9篇, 共发表SCI文章13篇。

The applicant has been working on the dynamics of cytoskeleton composed of major sperm protein (MSP) in nematodes sperm for a long period of time and making remarkable achievements in the last five years. (1) Revealed that spermiogenesis and sperm competition are mechanistically connected in nematodes (PNAS, 2012); (2) Reported that the micronutrient element zinc modulates sperm activation through the SPE-8 signaling pathway in Caenorhabditis elegans (Development, 2013; BBA, 2013); (3) Demonstrated that lipid microdomains composed of cholesterol and the glycosphingolipids are involved for signal transduction required for sperm activation in Caenorhabditis elegans (BBA, 2012); (4) Systematically investigated the transcriptome for the regulation of spermatogenesis and spermiogenesis in nematodes (BMC Genomics, 2011, 2014). Collaborating with worm researchers in China because of the applicant's expertise in electron microscopy study, he and his students as co-authors have published three impactful papers in high profile journals (Cell, 2009; Science, 2010; PLoS Genetics, 2013). Totally, the applicant has published 9 research articles as the corresponding author and 4 other research articles as one of co-authors since 2009.