长期从事隐孢子虫的宿主特异性、传播和优势亚型产生的遗传机制研究，成绩如下：1. 揭示了隐孢子虫及相关病原的宿主特异性规律，为病原的溯源和公卫意义评估奠定了基础；2. 阐述了人兽共患隐孢子虫虫种扩散与养殖业的关系以及动物-人的直接传播在发展中国家的重要性；3. 提出了遗传重组产生高毒力亚型的观点，并定位了毒力基因区域。发表SCI论文76篇，H指数19。近五年在EID, PLoS NTD, CMR, JCM和IJP等发表SCI论文40篇，其中第一或通讯25篇。近五年全部论文被他引941次。所建立的区分反刍动物隐孢子虫虫种的快速方法，阐述的隐孢子虫和贾第虫的宿主特异性特征，提出的微小隐孢子虫扩散与奶牛养殖相关的观点被广泛引用，使2篇论文入选ISI的Highly Cited Papers，3篇为期刊Most Cited Articles第一或第二名。做大会报告8次。2005年入选新世纪优秀人才。

The applicant has been working for many years on host specificity, transmission dynamics and genetic mechanism for the emergence of virulent and dominant subtypes of Cryptosporidium. Some major achievements in these areas within the last five years include (1) characterization of host specificity and host adaptation in Cryptosporidium spp. and other zoonotic pathogens, which are now used widely as the scientific basis for the tracking of infection and contamination sources and assessment of the public health significance of these pathogens in animals and environment; (2) elucidation of the relationship between the dissemination of zoonotic Cryptosporidium species and animal farming, discovery of the second cryptosporidiosis outbreak in humans in developing countries, and demonstration of the importance of zoonotic transmission in epidemiology of cryptosporidiosis in humans in developing countries; and (3) demonstration of the role of genetic recombination in the emergence of virulent and dominant subtypes of Cryptosporidium spp. in humans and animals in three recent publications, and localization of the virulence genes to a 129 kb region in chromosome 6 through comparative genomics and chromosome-wide sequence polymorphism scanning. These activities have led to the generation of 76 publications in international scientific journals, with an h index of 19. They include 40 publications within the last 5 years, in renowned international journals such as Emerging Infectious Diseases, PLoS Neglected Tropical Diseases, Clinical Microbiology Reviews, Journal of Clinical Microbiology, and International Journal for Parasitology with her as the first or corresponding author for 25 of them (including 5 papers in journals with IF > 6.0, and 13 papers in journals with IF = 3.0 - 5.9). Within the last five years, all of her publications were cited 941 times by peers. Her method for rapid diagnosis of Cryptosporidium species in ruminants, reviews on host specificity and host adaptation in Cryptosporidium and Giardia, and observations on the association between the world-wide dissemination of Cryptosporidium parvum and dairy cattle farming have been widely recognized and cited by peers. This has made two of her publications the Highly Cited Papers in Web of Knowledge, three of her publications No. 1 or 2 Most Cited Articles in their respective journals. She was a plenary speaker in eight international and national conferences including invited speaker for three of them and served as the session chair for five of them. Because of her excellence in research, the applicant received in 2005 the prestigious award “New Century Excellent Talents in Chinese Universities”.