青少年易受各种心理问题或精神疾病困扰，特别是社会-情绪发展相关的情绪-行为问题和危险行为等在该群体中的发生率高，危害性大。社会-情绪发展和功能受到多因素的影响，其中睡眠的重要作用不容忽视，而睡眠不足或睡眠紊乱与情绪行为问题的密切关系也为大量研究证实。此外，青少年或成人期的心理问题或精神疾病多源于儿童早期。我们前期研究通过建立规范的母婴队列，探索了母孕期睡眠对儿童肥胖及代谢相关疾病的影响。该研究还特别关注了早期睡眠对社会-情绪发展的影响，分别在婴儿出生后6周、3月、6月、9月、12月、18月和24月完成了睡眠、社会情绪发展及相关因素的多时点测量。在此基础上，我们将与港方合作，进一步扩大出生队列的样本，并在学龄前期、学龄期和青春期进行.睡眠、社会-情绪发展、社会-情绪功能以及相关因素的追踪测量，以考察早期睡眠和社会-情绪发展对青少年精神健康与疾病的持续影响。同时，双方均希望能够结合实验、神经影像学和分子遗传学等前沿技术探索睡眠对婴儿社会-情绪发展的影响和机制，考察两者对青少年精神健康与疾病的影响和机制。

Adolescents are subject to mental health or problems or diseases, especially for that emotional/behavioral problems and risk behaviors are closely related to social-emotional development, and have high prevalence and detrimental impact. Many factors influence social-emotional development, of which sleep play a critical role. Much evidence support the close relationship between insufficient sleep or sleep disturbances and emotional/behavioral problems. Furthermore, mental health problems or diseases in adolescents and adults usually develop from early childhood. Our previous study explored the impact of sleep during pregnancy on obesity and metabolic diseases through a formal mother-infant cohort. Another focus of the study was the impact of sleep in early childhood on social-emotional development. Sleep, social-emotional development and associated factors were respectively measures at 6 weeks, 3 months, 6 months, 9 months, 12 months, 18 months and 24 months after the child birth. Based on our early work, we would collaborate with Hong Kong side to increase the cohort size, and conduct follow-up assessments on sleep, social-emotional developments and associated factors at preschool age, school age and adolescence so as to examine the impacts of sleep and social-emotional in early childhood on mental health and disease in adolescence. In the meanwhile, both sides hope to explore the path and mechanism for the impact of sleep on early social-emotional developments, and for the combined impact of these two factors on mental health and disease in adolescence, by using the cutting-edge techniques of experiments, and neuroimaging and molecular genetics.

青少年易受各种心理问题或精神疾病困扰，特别是社会-情绪发展相关的情绪-行为问题和危险行为等在该群体中的发生率高，危害性大。社会-情绪发展和功能受到多因素的影响，其中睡眠的重要作用不容忽视，而睡眠不足或睡眠紊乱与情绪行为问题的密切关系也为大量研究证实。此外，青少年或成人期的心理问题或精神疾病多源于儿童早期。本课题组前期研究关注了4-18岁儿童和青少年情绪行为问题及其与睡眠的关系。本课题前期研究还关注了睡眠对早期社会-情绪发展的影响，分别在婴儿出生后6周、3月、6月、9月、12月、18月和24月完成了睡眠、社会情绪发展及相关因素的多时点测量。 与会期间，本课题组汇报了相关研究结果，并与港方达成了合作。双方均希望进一步扩大出生队列的样本，并在学龄前期、学龄期和青春期进行睡眠、社会-情绪发展、社会-情绪功能以及相关因素的追踪测量，以考察早期睡眠和社会-情绪发展对青少年精神健康与疾病的持续影响。同时，双方还希望能够结合实验、神经影像学和分子遗传学等前沿技术探索睡眠对婴儿社会-情绪发展的影响和机制，考察两者对青少年精神健康与疾病的影响和机制。随后，双方互访了睡眠实验室，并取得了初步的研究成果。