基于膜材料基本性能与项目组前期研究发现阐明膜微结构与中药成分相互作用的化学机理是陶瓷膜技术实现中药水提液高效分离的核心关键问题。提出：引入“多尺度”研究先进理念，建立表征“微结构衍化—分子溶液结构”相关性的膜过程传质结构模型，形成中药特种分离膜设计原理。因此，拟开展工作如下：（1）从项目组前期建立的218种中药复方及单方水提液的理化参数、共性高分子物质等数据中挖掘出影响膜过程的共性高分子物质类型、浓度和化学结构特征；（2）以黄连解毒汤生物碱、黄酮、环烯醚萜、苷类等代表性中药成分基本组成建立模拟体系，通过SEM、XPS、计算机仿真等实验手段测定与计算膜过程数据；（3）通过理论、模拟、实验三者互动的研究方法挖掘出微结构衍化和空间受限的机理，建立符合中药水提液特征的膜过程传质结构模型，揭示中药成分受限传递的特征分离规律。最终形成中药特种分离膜设计原理，为提升我国中药产业的自主创新能力奠定基础。

The basic properties of membrane material and the previous research shows the clarification of the chemical mechanism interaction between membrane microstructure and traditional Chinese medicine ingredient is the core of the key issues of the high efficient separation on water extract of Chinese medicines using ceramic membrane. Proposal: based on the method of Multi-scale, the model of structure and mass transfer on membrane was sat up to illustrating the correlation of membrane microstructure and structure of molecular in solution, and the design principle of special separation membrane for TCM was formed. Based on above consideration, this project intends to carry out works as follows: (1) according to our preliminary studies, the types, concentrations and chemical structure characteristics of identical polymer materials were elucidated by date mining from 218 kinds of Chinese herbal compounds and Chinese herbal medicines. (2) the model systems of alkaloids, flavonoids, iridoids and glycosides were established on the basis of Huang-Lian-Jie-Du decoction, and the data of membrane process were measured and calculated by means of SEM, XPS, computer simulation technology, etc. (3) the chemical mechanism of microstructure deriving and space-confined was clarified using the research method of the interactions of theory, simulation and experiment. Meanwhile, the mass structure transfer model of membrane process for TCM was established, and the original separation law of components from Chinese herbal medicines was revealed on under the action of confined transfer. Finally, the design principle of special separation membrane for TCM was elucidated. This study would lay a foundation for promoting the independent innovation ability of Chinese traditional medicine industry.