炎症是肿瘤的重要特征之一，近年来大量研究表明慢性炎症与肝细胞癌的发生发展有着紧密的关系。肝癌是我国患病率很高的肿瘤之一，其发病率和死亡率长期居高不下，每年全球新发病例的大约50%来自中国。在我国，肝癌的发生发展与乙型肝炎病毒导致的慢性肝脏炎症密切相关，但迄今为止，对于慢性炎症向肝癌转归以及炎症微环境对肝癌侵袭转移的具体分子机制仍未得到详尽阐述，也因此导致了对于肝脏慢性炎症引起的各种疾病(包括肝癌)缺乏行之有效的干预手段。本群体前期在群体项目等的资助下，协同创新，在肝脏炎癌转化机制的基础和应用研究方面取得了重要进展，在Nature Genetics、Nature Communication、J. Clinical Oncology、Gut等著名期刊发表论文超过100篇。我们将在前期工作的基础上，继续探索慢性肝脏炎症促进肝细胞恶性转化的分子机制与信号调控机制，以期最终为肝癌炎癌转换提供潜在的诊断、预后评估标志物及新的干预策略。

Inflammation is an important characteristic of cancer, and numerous recent studies have demonstrated the intimate relationship between chronic inflammation and hepatocelluar carcinoma (HCC). Moreover, about half patients newly diagnosed as HCC reside in China annually. In China, the carcinogenesis and progression of HCC strongly correlated with chronic hepatitis B, making it a critical task to clarify the detailed mechanism underlying chronic inflammation induced HCC onset and progression. This Creative Research Group is composed of long-term cooperative research groups focusing on hepatitis and HCC from the second military medical university, and the main goal of the continued project is to further investigate the molecular mechanism of chronic liver inflammation induced hepatocarcinogenesis and progression, and to eventually provide potential biomarkers for HCC diagnosis and prognosis prediction, as well as novel intervention strategies.