前期研究表明,穴位埋线能够调节OVX大鼠与情绪相关的氨基酸（发表于2014年Nature子刊Scientific Reports）。已知，Glutamate-GABA介导了脑的90%以上的信号转导，是脑神经活动最重要的神经递质，抑制性GABA减少导致Glutamate-GABA平衡失调是惊恐障碍（PD）产生的根本原因。围绝经期惊恐障碍（PPD)的防治是当前值得重视的一大课题。临床研究表明，穴位埋线可以改善PPD的焦虑症状，考虑与脑神经活动有关，但是，机制不清。本实验采用磁共振（fMRI、1H-MRS）技术，以围绝经女性为研究对象，遵循随机对照原则，比较健康志愿者与PPD患者恐惧网络fMRI特征及杏仁核、岛叶Glutamate-GABA含量，对比穴位埋线与阿普唑仑的疗效,结合游离氨基酸的变化，探索PPD的生物标记物及穴位埋线的干预机制，是向临床转化的创新性研究，对创新治疗手段具有重要的意义。

Previously, we showed that metabonomic analysis revealed efficient ameliorating effects of acupoint catgut embedding on the Ovariectomized rats in amino acids alterations in terms of emotional regulation (Zhang liming,et al. Scientific Reports 2014). It's well known that losing equilibrium between Glutamate and GABA(overactivation of glutamatergic system) is the fundamental cause of panic disorer. Together, these two neurotransmitters constitute to more than 90% of all neurotransmissions, creating excitatory/inhibitory forces in the brain. Perimenopausal panic disorder (PPD) is a typical psychosomatic disease during climacteric period wich attracts great concern in terms of its prevention and treatment at present. Clinically, we found that catgut embedding in points has anxiolytic effect in PPD,which is probably relative to balance the brain neural activation.However, The underlying molecular mechanism of PPD and its interaction between catgut embedding in acupoints still remain unknown. Thus, we propose to use functional Magnetic Resonance (fMRI) and Proton Magnetic Resonance Spectroscopy(1H-MRS) to investigate the status of brain equilibrium, excitation and inhibition. A randomized clinical trial comparing healthy control of childbearing women with PPD is done to examine changes in clinical outcomes and brain neural activations. Changes in brain neural activation and Glutamate-GABA concentration in amygdala and insula is also explored with the intervention of catgut embedding in points in comparison with Alprazolam. Besides, the free amino acid of peripheral blood is checked to probe the biomarker of PPD and its interactive underpinning of catgut embedding in points. It's an innovative research in translational medicine which has clinical significance in exploring innovative treatment.