PCOS-IR是PCOS发展至严重阶段、内分泌和糖脂代谢紊乱共存性疾病，具有高度异质性、临床多态性及糖尿病、心血管疾病、代谢综合征、子宫内膜癌等的远期发病风险，治愈难度很大。PCOS-IR拥有多种信号传导分子，如炎症因子是PCOS-IR的重要发病机制；胰岛素样生长因子IGF-1可经与IRS结合参与疾病发生发展；胃动素相关肽ghrelin与血清T、INS和IR间存在负相关关系。根据“冲脉隶于阳明”理论，阳明（胃肠）的功能正常与否直接影响月经与生育，是调节“肾气-天癸-冲任-胞宫”生殖轴的重要环节。本课题拟以PCOS-IR模型大鼠为研究对象，采用益肾祛浊方进行干预，观察大鼠垂体、卵巢、胃肠道的激素受体、炎症因子（IL6和IL18）、INS、IGF-1及上述组织ghrelin的表达变化，探索益肾祛浊方多靶点多层次的作用，阐明运用阳明理论调治生殖障碍性疾病的机制，为中医妇科学经典理论提供实验证据。

PCOS-IR, reflects in endocrine disturbance, and glucose and lipid metabolism disorder, with high heterogeneity, and clinical polymorphism, is the severe stage of PCOS. It’s difficult to cure since its long term risk of diabetes, cardiovascular disease, metabolic syndrome, endometrial carcinoma, and so on. Inflammatory factor is the important pathogenesis of PCOS-IR. IGF-1 paticipates in the development of the disease by combining with IRS. There is a negative correlation between ghrelin and testosterone, ghrelin and insulin, and ghrelin and insulin resistance. Based on CHONG MAI belonging to YANG MING theory, gastrointestinal function(YANG MING) is a critical point to adjust the TCM reproduction axis, and it has a direct influence over menstruation and fertility. This study used PCOS-IR rats model as the research object. The rats model are intervened by tonifying the kidney and eliminating the turbidity. The study is to observe the hormone receptors on pituitary, ovary, and intestines of rats, as well as IL-6, IL-18, insulin, IGF-1, and the expression of ghrelin. The aim is to explore the multi target effect of YI SHEN QU ZHUO formula, to explain the mechanism of using YANG MING theory to treat reproductive disorders, and to provide experimental evidence for the classical theory of TCM Gynecology.