主要从事代谢异常心肌损伤和保护的研究。（1）发现代谢异常状态下，存在氧化应激、脂毒性-自噬钝化级联反应，导致细胞损伤蛋白清除障碍；（2）发现代谢异常状态下，内质网应激致线粒体损伤诱发细胞器损伤瀑布效应；（3）首次证实ALDH2对代谢异常心肌损伤的保护作用。以第一或通讯作者在Circulation等期刊发表SCI论文30篇，总影响因子195.4，其中IF大于5分的25篇，被Physiological Reviews（IF:29.041）等著名期刊他引280余次。两度获美国怀俄明大学心血管研究中心最佳研究员奖，总后勤部优秀青年科技人才扶持对象。现任Cardiovascular Diagnosis and Therapy, BioMed Research杂志编委，Biochim Biophys Acta等三个SCI杂志的特邀编辑，拟探讨ALDH2对糖尿病心肌线粒体质量控制的调控作用及分子机制。

The applicant has been engaged in the understanding of the pathogenesis and therapeutics of myocardial injury under metabolic diseases. The applicant’s major scientific contributions encompass (1) revealing oxidative stress and lipid toxicity-initiated autophagy and novel mechanisms behind myocardial injury in metabolic disorders from the perspective of compromised protein accumulation; (2) identifying ER stress induced mitochondria damage as caspase effect and novel mechanisms of myocardial injury in metabolic disorders from the perspective of organelle damage;（3）discovery of aldehyde dehydrogenase 2 (ALDH2) governed bi-directional autophagy regulation as the upstream switch protein to promote removal of damaged proteins. ALDH2 protects myocardial proteins and organelles including endoplasmic reticulum and mitochondria from pathological insults in metabolic disorders. These findings have shed some promises towards identification of new therapeutic targets in heart disease. Over the past five years, the applicant has published 30 papers in first-rated journals as the first or corresponding author. Among them, 25 publications were published in journals with impact factor higher than 5. The combined impact factor reaches 195.4 with 280 citations from others including Physiological Reviews with IF of 29.041. The applicant has served as the principal investigator for two NSFC grants and played a major role in research awards from National Institutes of Health. The applicant was also honored as the Outstanding Researcher twice in the Center for Cardiovascular Research and Alternative Medicine at the University of Wyoming and received the prestigious awards as an excellent young technical talent in the General Logistics Department and Shannxi provience. Serving as a guest editor for journals such as Curr Pharm Design and BBA Mol Basis Disease, the applicant edited special issue focused on metabolic disorder. The applicant also serves on editorial board for Cardiovascular Diagnosis and Therapy, BioMed Research. This proposal is aimed to examine the role of ALDH2 in diabetic cardiomyopathy as control protein of mitochondrial quality control, in an effort to identify new therapeutic target for cardiac dysfunction under metabolic syndrome.