The Graeter group at PICB is at the forefront of using molecular simulations to study protein mechanics, and in particular analyzing the networks of force distribution in mechanically perturbed proteins. Over the last year, I have been working in this group to develop new techniques for calculating the intrinsic stress distribution in proteins. In the coming year I plan to apply my new methods to study different proteins from a range of different structural families, with the specific goal of inferring a set of general relationships between molecular force distribution and function. I will pay special attention to allosteric proteins involved in cellular signaling networks, thus contributing to our institute's overall goal of elucidating the path from genotype to phenotype.