因血脑屏障的存在，许多药物经常规递药途径无法进入脑实质，限制了对脑部疾病的治疗；鼻黏膜和脑之间存在特殊通路，使药物经鼻入脑成为可能。研究发现：冰片能促进川芎嗪经鼻吸收迅速入脑，其机制与延长鼻黏膜黏液纤毛传送时间有关；经鼻腔给药不会额外增加药物的全身性和脑部不良反应；在严格控制用量和时间的情况下，冰片不会对鼻黏膜纤毛造成不可逆的损害。本研究拟通过测定经鼻腔递送的川芎嗪在不同时间点进入脑脊液的药量、纤毛摆动频率、杯状细胞黏蛋白表达水平、纤毛上皮细胞内Ca2+和ATP浓度、鼻黏膜超微结构等指标变化，评估冰片对它们的影响，从多层次对冰片促进川芎嗪经鼻吸收入脑与鼻黏膜黏液纤毛传输系统关系进行探讨。根据开窍药"引药上行"理论，在现有研究基础上，探讨冰片促进川芎嗪经鼻黏膜吸收靶向脑部的机制，为开发脑靶向给药系统提供一种有力的工具，拓宽冰片的应用范围，丰富开窍药引药上行的现代内涵。

Owing to the presence of blood-brain barrier, lots of medicines can not enter brain parenchyma by normal delivery way, which restrains their effect on brain diseases. The special pathway between nasal mucosa and brain make it possible for medicines to bypass blood-brain barrier and reach the brain. Our study showed that: borneol promoted nasal absorption of ligustrazine into brain. And its mechanism was connected with prolonging mucous cilia transmission time (MCT). Nasal administration did not increase systemic and brain side effects. Borneol did not cause inreversible damage of nasal mucous cilia on condition that its dosage was limited. In this research, the influence of borneol will be evaluated on concentration of ligustrazine nasal administrated in cerebrospinal fluid at different time point, MCT, Ciliary beat frequency, mucin expression level of goblet cells, concentration of Ca2+ and ATP in ciliated epithelial cells, and ultrastructure of nasal mucous membrane. In this way, the relationship between borneol promoting lingustrazine nasal administrated absorbed into brain and nasal membrane mucus cillia transmission system were investigated. According to the theory of "aromatic stimulant for resucscitation guiding medicine upward", the mechanism of borneol promoting lingustrazine absorbed by nasal membrane targeting brain was investigated. And this study will provide a powerful instrument for developing brain target adminstration system, broaden the application range of borneol, richen mordern connotation of the theory of "aromatic stimulant for resucscitation guiding medicine upward".