中文摘要
生命科学扎基化学发展十分迅猛，化学对接生命科学应用前景宽阔。生命小分子乃至大分子DNA的识别与检测是当今世界科学研究一个重要方向。电化学传感是生物化学传感的一个主要领域，随着纳米技术的发展，稀土纳米材料及其掺杂复合材料用于生物电化学传感器制备、识别和实测异军突起。本项目以稀土纳米及其掺杂复合材料为基质，以电化学传感器为载体，以DNA及生物小分子为对象，开展了系列合成、制备、性能、识别、检测及规律的研究。先后合成16种稀土纳米材料（粒、棒、晶、簇）和稀土纳米复合材料；先后制备8种DNA电化学传感器，用于DNA的识别或A、G的检测，1种修饰电极用于尿嘧啶的检测，10余种生物、药物、环境小分子电化学传感器。先后建立了8种识别和检测DNA的新方法，10余种小分子电化学分析法。发表论文38篇（2006年11月前已接受而来不及注基金项目号的5篇），其中被SCI收录30篇，IF > 3.0 的论文10余篇。
英文摘要
The development of life sciences based on chemistry is very swift and the prospect of chemistry connected life sciences is very wide. The recognition and detection of small molecules of life and even large molecules as DNA is the one of the most important scientific research topics in the world today. Electrochemical sensing is a major field of biochemical sensing. With the development of nanotechnology, the technology of rare earth nanomaterials and their doping composite applying in the fabrication of bio-electrochemical sensor becomes a new force suddenly coming to the force. In this project, based on the nano-rare earth and their doping composite, with the electrochemical sensors as the carriers, and DNA and small molecules of life as the target, we carried out a series of research on the synthesis, preparation, function, detection and rule. We have synthesized 16 kinds of rare earth nanomaterials (particles, rods, crystals and clusters) and rare earth nanocomposite, prepared 8 kinds of electrochemical DNA sensors for the recognition of DNA and detection of A and G, 1kind of modified , electrode for the detection of uracil, more than 10 kinds of electrochemical sensors of biological, pharmic and enviromental small molecules, set up 8 kinds of new method to detect and recognize DNA, more than 10 kinds of electroanalytical method on small molecules, published 38 pieces of articles, (including 5 papers accepted before Nov. late to note the fund number), among them 30 papers from SCI, and more than 10 papers IF > 3.0.
结题摘要
生命科学扎基化学发展十分迅猛，化学对接生命科学应用前景宽阔。生命小分子乃至大分子DNA的识别与检测是当今世界科学研究一个重要方向。电化学传感是生物化学传感的一个主要领域，随着纳米技术的发展，稀土纳米材料及其掺杂复合材料用于生物电化学传感器制备、识别和实测异军突起。本项目以稀土纳米及其掺杂复合材料为基质，以电化学传感器为载体，以DNA及生物小分子为对象，开展了系列合成、制备、性能、识别、检测及规律的研究。先后合成16种稀土纳米材料（粒、棒、晶、簇）和稀土纳米复合材料；先后制备8种DNA电化学传感器，用于DNA的识别或A、G的检测，1种修饰电极用于尿嘧啶的检测，10余种生物、药物、环境小分子电化学传感器。先后建立了8种识别和检测DNA的新方法，10余种小分子电化学分析法。发表论文38篇（2006年11月前已接受而来不及注基金项目号的5篇），其中被SCI收录30篇，IF > 3.0 的论文10余篇。