囊泡的转运及其与细胞膜的融合过程是神经递质释放、内分泌激素的分泌、蛋白质转运等细胞功能活动的基础。细胞内囊泡转运和融合涉及很多科学问题，本项目集中回答囊泡与质膜融合最后步骤中的三个重要科学问题：1）囊泡融合的触发机制；2）囊泡启动的分子机制；3）囊泡特异性调控的分子基础。这三个问题之间有着紧密的联系，都会涉及到 Synaptotagmin、SNARE 蛋白以及与它们相互作用的蛋白。这些问题是目前本领域的国际前沿热点，对于阐明囊泡转运和融合的机理具有重要意义。

Vesicle transport and fusion with the plasma membrane provide the basis for many cellular processes, such as neurotransmitter release, secretion of neuropeptide and protein trafficking. Many scientific fields are involved in exploring the question that how vesicles are transported and fused with surface membrane. Our project focus on the identifying the molecular identities of the last three steps in vesicle fusion: 1) The mechanism for the initiation of vesicle fusion; 2) The molecular mechanism of vesicle fusion; 3) The molecular basis of specific vesicle regulation. These three questions are closely related, involving functional study of essential proteins such as synaptotagmin, SNARE proteins and etc. These questions are currently the hot topic in this field, and is very crucial to the understanding of vesicle transport and fusion.

囊泡的转运及其与细胞膜的融合过程是神经递质释放、内分泌激素的分泌、蛋白质转运等细胞功能活动的基础。细胞内囊泡转运和融合涉及很多科学问题，本项目集中回答囊泡与质膜融合最后步骤中的三个重要科学问题：1）囊泡融合的触发机制；2）囊泡启动的分子机制；3）囊泡特异性调控的分子基础。这三个问题之间有着紧密的联系，都会涉及到 Synaptotagmin、SNARE 蛋白以及与它们相互作用的蛋白。这些问题是目前本领域的国际前沿热点，对于阐明囊泡转运和融合的机理具有重要意义。