1、建立了蠕虫形聚合物刷结构和官能团精细控制的方法。得到了通过金属离子配位PEG修饰的树状化聚合物，引入了冠醚基团获得具有主客体作用的树状化聚合物，得到具有均匀蠕虫形貌、并可取向形成多级有序结构的聚合物纤维。将树状化聚合物作为分子组装单元，合成了各种精细结构的聚合物刷，并研究了它们在药物输送中的应用。2、建立并系统研究了通过可凝胶化嵌段共聚物本体的微相分离，制备溶液分散的球形、柱形、薄层形等各种形貌的聚合物纳米材料，方法普适简便。研究了两嵌段、三嵌段共聚物等多种结构和反应性的嵌段共聚物，获得了多种精细纳米结构的纳米聚合物。3、基于新型聚合物开展其在材料应用的研究，通过环糊精和PEG的作用建立了碳纳米管杂化的超分子水凝胶，合成出具有多级自组装行为的超分子嵌段共聚物；用超分子聚合物可注射水凝胶负载纳米化疗抗癌药物，提出水凝胶－纳米药物粒子－自由药的分布释放机制。这些新材料具有环境响应性，为其在生物医药中的应用提供了新材料。共发表SCI论文45篇，培养博士研究生14名。作为项目负责人承担基金会重大项目1项。担任Polymer的副主编，Macromolecules编委成员。

(1) An approach to fabricate and precisely functionalize wormlike polymer brushes has been built. By this chemistry, novel dendronized polymers functionalized with PEGs tethered through metal complexation and crown ether units have been prepared. Codendronized polymers with wormlike morphologies have been prepared and they exhibited hierarchical ordered structure from molecular level to macroscopic scale. Moreover, dendronized polymers have been applied as building blocks to prepare various nanosized polymers. Also the amphilphilic polymer brushes have been obtained and their drug delivery properties have been evaluated. (2) A facile and generalized approach to produce polymeric nanoobjects with different shapes has been developed. By self-assembling, crosslinking and dispersing in solvent, various stable polymer particles of spherical, cylindrical and sheetlike shapes have been obtained. They are applying to study the shape resulted properties. (3) By using chemistry obtained above, novel well-defined polymers have been studied for materials application. The cyclodextrin induced polymer hydrogels have been applied to hybridize with functional species like carbon nanotubes and these novel materials demonstrate stimuli-responsive properties. The hydrogels hybridized with the nanoparticles bearing anticancer chemotherapy drugs exhibit new stepwise delivery properties. Under support, 14 PhD students have been graduated and 45 papers have been published so far. The principal becomes an Associate Editor of Polymers journal and Editorial advisory board of Macromolecules journal.

1、建立了蠕虫形聚合物刷结构和官能团精细控制的方法。得到了通过金属离子配位PEG修饰的树状化聚合物，引入了冠醚基团获得具有主客体作用的树状化聚合物，得到具有均匀蠕虫形貌、并可取向形成多级有序结构的聚合物纤维。将树状化聚合物作为分子组装单元，合成了各种精细结构的聚合物刷，并研究了它们在药物输送中的应用。2、建立并系统研究了通过可凝胶化嵌段共聚物本体的微相分离，制备溶液分散的球形、柱形、薄层形等各种形貌的聚合物纳米材料，方法普适简便。研究了两嵌段、三嵌段共聚物等多种结构和反应性的嵌段共聚物，获得了多种精细纳米结构的纳米聚合物。3、基于新型聚合物开展其在材料应用的研究，通过环糊精和PEG的作用建立了碳纳米管杂化的超分子水凝胶，合成出具有多级自组装行为的超分子嵌段共聚物；用超分子聚合物可注射水凝胶负载纳米化疗抗癌药物，提出水凝胶－纳米药物粒子－自由药的分布释放机制。这些新材料具有环境响应性，为其在生物医药中的应用提供了新材料。共发表SCI论文45篇，培养博士研究生14名。作为项目负责人承担基金会重大项目1项。担任Polymer的副主编，Macromolecules编委成员。