Strepenlactone是我们前期从海洋链霉菌Streptomyces sp. NS0454菌株中分离和鉴定的一类新颖的beta-内酯类化合物，骨架特殊且具有较强的脂肪酶抑制活性。本课题将综合多学科的优势，鉴定strepenlactone的生物合成基因簇，揭示其生物合成途径，阐明骨架环系的形成机制，研究关键酶的功能和催化机理，并通过基因挖掘和组合生物合成等技术发现更多新型beta-内酯化合物，为肥胖症等疾病的治疗提供新型药源分子。

Strepenlactones A-C, a group of novel beta-lactone-type compounds, were isolated from a marine Streptomyces sp. NS0454. Strepenlactones A-C possess a novel carbon skeleton differing from all other known compounds in literature, and show potent inhibitory activity towards lipase. In this project, we will carry out a multidisciplinary study 1) to discover the biosynthetic gene culster and elucidate the whole biosynthetic pathway for strepenlactone, 2) to understand the functions of key enzymes, and 3) to construct a beta-lactone compound library through genome mining and combinatorial biosynthesis for discovering novel lead compounds.