苯及其衍生物是工业中最广泛使用的化工原料和工业溶剂。长期接触苯可导致白血病、再生障碍性贫血等恶性疾病的发生，严重危害了职业工人的健康和生命，然而其致病机制尚不清楚。本课题组前期研究结果显示，在苯暴露人群外周血中，miR-24呈高表达状态。同时，在10例苯致急性粒细胞白血病患者骨髓中miR-24均异常高表达，提示miR-24可能参与了苯致白血病的发生发展。通过生物信息学分析，我们发现苯及其代谢物引起的内质网应激反应中关键基因ATF4可与miR-24-2启动子区结合。在后续研究中，我们拟从人群、动物和细胞三个层面进一步探讨苯介导的内质网应激与miR-24之间的相互作用，从表观遗传学角度阐明苯中毒引起急性粒细胞白血病的作用机制，为苯致急性粒细胞白血病的诊断与治疗提供新的研究方向和治疗策略。

Benzene and its derivatives is widely used in industry as industrial chemical raw materials and industrial solvent. Long-term exposure to benzene can cause leukemia, aplastic anemia and other malignant diseases. However, the pathogenic mechanism of benzene induced leukemia is not clear. Our previous study displayed that miR-24 was abnormally high expressed in the peripheral blood in individuals with benzene exposure. Furthermore, we investigated miR-24 in bone marrow of 10 patients with benzene induced leukemia, and it was also over-expressed. These results suggested that miR-24 may participate in the development of benzene induced acute myelocytic leukemia. Through bioinformatics analysis, we found that ATF4, the key gene involved in endoplasmic reticulum stress caused by benzene and its metabolites, could bind to miR-24-2 promoter region. In the following study, we tend to verify the molecular mechanism of miR-24 in benzene induce leukemia. This study has strong theoretical basis and clinical significance, which could also provide a noble direction in the prevention and therapy of benzene induced acute myelocytic leukemia.