研究表明食品中雌激素类物质如大豆异黄酮（SIF）和双酚A（BPA）对神经细胞具有截然相反的生物学效应（SIF和BPA分别促进或抑制神经细胞凋亡）。文献调研发现，SIF和BPA主要通过雌激素受体信号通路调控AD，该通路可诱导孤儿核受体TR3表达量与亚细胞定位发生改变，而TR3对神经细胞凋亡具有双向调节作用，因此本项目假设不同雌激素类物质对AD的调控差异与TR3密切相关，拟以食品中典型雌激素类物质SIF和BPA为研究对象，建立不同雌激素类物质干预的AD模型，分别从分子、细胞和整体动物水平对比AD发生与转归过程中TR3的差异，阐明SIF和BPA对AD调控的TR3相关通路的变化，探索食品中不同雌激素类物质调控差异的新机制。本研究不仅可以为食品中雌激素类物质风险评估提供新方法，而且还是有效控制食品中雌激素类物质危害、充分发挥其医疗价值的有益新探索。

Studies show that estrogenic substances such as soy isoflavones (SIF) and bisphenol A (BPA) have diametrically opposite biological effects on neurons (SIF inhibit neuronal apoptosis and BPA promote neuronal apoptosis). The literature researches found that SIF and BPA regulate AD mainly through estrogen receptor signaling pathway, which can induce the expression of orphan nuclear receptor TR3 and the subcellular localization changes. TR3 has a two-way regulation of neuronal apoptosis. Therefore, this project assumes that the regulatory differences between different estrogenic substances to AD may be closely related to TR3. We use the typical foodborne estrogenic substances SIF and BPA as the objects of study,establish the AD model intervened by different estrogenics,compare the differences of TR3 during AD conversion process at the level of cells, molecules and animals, aiming to clarify the TR3-related signal changes during the regulation of SIF and BPA to AD, explore new mechanism of regulatory differences of different foodborne estrogenic substances. This study provides a new method for the risk assessment of estrogen substances in food, as well as a very valuable attempt to effectively control the hazard of foodborne estrogenic substances ,give full play to their medical value.