鞣质（Tannin）是广泛存在于植物中的一类植物多元醇（酚）类次生代谢产物，随着其生物活性的逐渐显现，近年来鞣质类化合物作为一类新的活性有机物群日益受到重视。鞣花鞣质（Ellagitannin）是可水解鞣质中的重要类型，研究证实Urolithins是鞣花鞣质在体内肠道菌群作用下的代谢物，是鞣花鞣质在体内发挥生物活性的物质基础，但Urolithins体内吸收、分布、排泄及代谢转运调控机制尚未阐明。本项目是在前期研究基础上的连续深入研究，采用化学和代谢组学相结合的方法对Urolithins及其衍生物的代谢转运规律和生物活性调控机制进行全面系统研究，阐明鞣花鞣质及Urolithins发挥药理活性的机制及代谢通路，同时基于活性导向对Urolithins进行适当结构修饰，通过细胞活性筛选寻找活性高、毒性小的先导化合物，为将鞣花鞣质及Urolithins开发成一种新的、安全有效的天然药物提供科学依据。

Tannins are plant polyphenolic secondary metabolites ,which are widely found in plants. With the gradual emergence of its biological activity, tannins have been paid more and more attention as a new class of active organic groups in recent years. Ellagitannin is an important type of hydrolyzable tannin，studies have shown that urolithins are the metabolites of ellagitannin under the action of intestinal flora in the body and are the material basis for the biological activity of ellagictannin in vivo. But it has not yet elucidated about urolithins in vivo absorption, distribution, excretion and metabolic transport regulation mechanism. This project is a continuous and in-depth study based on the previous research, using a combination of chemistry and metabonomics to carry out a comprehensive and systematic study of urolithins' metabolic transport laws and their biological activity regulation mechanisms.It also will illuminate the mechanism and metabolic pathway of ellagitannin and its metabolites urolithins. At the same time, based on the activity-oriented modification of urolithins, the viable compounds with high activity and low toxicity are selected by cell activity screening .These will provide scientific basis for the ellagitannin and its metabolites urolithins developed into a new, safe and effective natural medicine.