孤儿核受体Nur77是核受体家族的重要一员，可被多种细胞因子诱导表达，参与调控细胞的增殖、分化、凋亡和自噬等，具有多种生物学功能，其表达和功能异常会导致肥胖症等疾病。我们前期研究结果显示海洋来源靶向Nur77的小分子化合物XS-284具有抑制肥胖症的作用。我们利用瘦素(leptin)突变型ob/ob肥胖小鼠和高脂诱导的DIO小鼠等肥胖症动物模型，重点研究XS-284及其衍生物如何通过靶向孤儿核受体Nur77抑制肥胖症，探索海洋来源小分子化合物XS-284在脂质调控中的新型作用机制，为寻找新的肥胖症潜在治疗靶点和治疗药物提供重要实验依据。.

Orphan Nuclear Receptor Nur77 is an important member of the nuclear receptor family, which can be induced by a variety of cytokines and participate in the regulation of cell proliferation, differentiation, apoptosis and autophagy. The abnormal expression or dysfunction of Nur77 can lead to obesity, cancer, diabetes, atherosclerosis or other major diseases. Our preliminary studies showed that a marine bioactive substances called XS-284 that targeted nuclear receptor Nur77 has an inhibitory effect on obesity.We use leptin mutant ob/ob obese mice and DIO obese mice induced by high fat diet as obesity animal model, focuses on the study of the inhibitory effect on obesity of XS-284 and its derivatives, explore the new mechanism of the role of XS-284 in lipid regulation. This research will provide an important theoretical and experimental basis for in-depth understanding of obesity and the search for new targets and potential therapeutic drugs s for the treatment of obesity.