心血管疾病（cardiovascular disease, CVD）是发病率、致残致死率高的重大慢性疾病。心血管早期损伤是CVD发病过程中的重要生物学事件。研究影响心血管早期损伤指标（血压、血糖和血脂）的环境和遗传因素，将CVD防治重心前移，是探索CVD病因和预防对策的重要手段。噪声可通过调节应激激素来促进CVD发生，但噪声和应激激素合成酶遗传变异是否影响心血管早期损伤尚待研究。.本课题采用前瞻性研究设计，在某卷烟厂1,218名工人中开展以下研究：①动态观察2012~2018年间职业噪声暴露强度和暴露时间对心血管早期损伤指标的影响。②采用生物信息学方法筛选应激激素合成酶基因上有潜在功能的遗传变异，并探讨其对噪声所致心血管早期损伤指标动态变化的调节作用。③采用体外实验，阐明心血管早期损伤易感位点的分子生物学功能。为职业易感人群的筛查和早期健康监护提供科学依据，并进一步阐明CVD的发生机制。

Cardiovascular disease (CVD) is one of chronic diseases with high morbidity, disability rate and mortality. The initial cardiovascular damage is a key event in the development of CVD. Thus, the investigation of environmental and genetic factors for initial cardiovascular damage indexes (blood pressure, glucose and blood lipids) is a crucial way for etiology and prevention of CVD.Noise is supposed to induce CVD by modifying the levels of stress hormones. However, whether occupational noise and genetic variants in stress hormones biosynthesis pathway are associated with initial cardiovascular damage is unclear. .This prospective study investigates the following issues: ①The dynamic associations between occupational noise and initial cardiovascular damage indexes from the years of 2012 to 2018. ② The associations between potential functional genetic variants in stress hormones biosynthesis pathway and initial cardiovascular damage indexes. These genetic variants were screened by bioinformatics methods. ③ The biological function of genetic variants which are associated with initial cardiovascular damage indexes would be investigated by in vitro tests. Our study will provide a scientific basis for the early screening and health care of susceptible individuals in the occupational noise-exposed populations. It will also benefit for the clarification of CVD mechanisms.