职业紧张作为一个影响职业人群身心健康的重要心理社会因素，现已成为当今世界重要的职业卫生问题之一。已有研究表明职业紧张会引起职业人群心理健康问题，继而导致心理障碍的发生，甚至诱发重大疾病。且学者们普遍认为心理社会应激在心理疾病的发生进程中起着重要作用，原因很可能是由于应激反应导致下丘脑-垂体-肾上腺轴功能异常，从而对机体健康造成不良影响。同时，遗传因素在其中也起着重要作用。课题组前期对新疆不同职业人群的研究表明职业紧张因素是引起职业人群心理障碍发生的主要危险因素。但已有的研究大多是建立在横断面研究或病例对照研究的基础上，因此缺乏有力的病因学证据。为此本项目在前期研究的基础上预期通过队列研究明确新疆煤矿工人心理障碍的流行现况、时间趋势及其发生机制，并建立心理障碍发病的预测模型，从而进一步证实职业紧张因素与心理障碍之间的病因学关系，为职业人群职业紧张及心理障碍的防治提供科学依据。

Occupational stress as an important social psychological factors can influence the physical and mental health of occupational population. And occupational stress has become a very important issue of occupational hygiene. The previous studies showed that occupational stress can lead to unhealthy psychological illness and mental disorder in different population, even cause serious illness. And scholars generally believe that psychosocial stress plays an important role in mental disease, the reason is may well due to that the stress leads to the hypothalamic-pituitary-adrenal axis dysfunction, thus cause bad effects to the body health.At the same time, in which genetic factors also play an important role. In previous study, we have found that occupational stress factors is the main risk factors of mental disorder in different occupational populations in Xinjiang. However, there was a few positive etiological basis in previous cross-sectional and case-control studies. So in this project, we prepare to focus on the incidences ,time trend and pathogenesis of mental disorder of coal miner in Xinjiang, and intend to establish the predictive model of mental disorder. So the scientific basis on the detection and prevention of hypertension and psychological disorder can be provided.