毛细管电泳（CE）技术用于手性药物分离已经得到广泛关注。手性选择剂的使用是对映体拆分能否成功的关键，面对日益繁重的手性分离任务以及对高效率的不断追求，新型手性选择剂的开发仍然是一项最为基础和核心的研究内容。离子液体作为一种新型材料，近年来在药物分析领域已表现出非常好的应用前景。但在CE手性分离方面，有关离子液体的研究仍然处于起步阶段。本项目拟系统开展基于离子液体手性选择剂的CE手性分离研究工作，构建手性离子液体与传统手性选择剂（环糊精、多糖、抗生素等）配伍的二元协同拆分体系，并进一步发现集“体系修饰”和“手性识别”功能于一体的新型离子液体手性选择剂。采用计算机分子模拟，从分子水平上研究手性识别机理。研究成果直接用于创新药物的对映体分离和光学纯度检查。本项目的实施将推动离子液体技术在CE手性拆分领域的发展，较大程度地提高手性药物分析水平，具有较高的学术意义和应用价值。

Chiral Separation by capillary electrophoresis (CE) has received increasing attention. The use of chiral selectors is critical for a successful enantiomeric separation. Therefore, the development of novel chiral selectors remains an urgent priority for heavy enantioseparation tasks and the pursuit of higher efficiency. The application of ionic liquids (ILs) in pharmaceutical analysis has proven to be a promising approach in recent years; however, research on the use of ILs for chiral separation is still in its preliminary stage. In this project, synergistic systems consisted of chiral ILs and conventional chiral selectors (cyclodextrins, polysaccharides and antibiotics) will be established. Novel ILs chiral selectors which have combined “system modification” and “enantiorecognition” properties will be developed. Furthermore, research on chiral recognition mechanism will be carried out by means of computer molecular simulation. The research achievements will be used for enantioseparation and optical purity test of new chiral drugs. The project is expected to facilitate the application of ILs in CE enantioseparation, as well as the development of chiral separation science. Thus, it presents a high-level of academic value, and is of great importance in practical application.