肥胖已经是全人类面临的重要健康问题之一，其影响因素众多，其中由于倒班制引起的肥胖问题日渐突出。项目组已有研究结果显示倒班劳动者与肥胖存在关联。研究发现倒班能引起机体生物节律的紊乱，从而造成机体肥胖，但具体机制尚不明确。因此，本研究拟从人群、动物、细胞三个层次，运用余弦软件分析、RNAi等手段，确认倒班与肥胖的关联，探索褪黑素是否通过影响脂肪组织钟基因及细胞增殖调节因子（c-Myc）的节律最终影响脂肪细胞的增殖，阐明倒班引起的肥胖可能通过褪黑素-钟基因-脂肪合成相关基因途径实现。本研究的完成将为研究职业人群肥胖问题提供新的思路，并为职业人群的健康促进提供理论依据。

Obesity has been one of the most important health problems for human. It may be related to several mechanisms, shift work has been a marked one. We found that there were significant correlations between shift work and obesity. Shift work can disturb the biological rhythm, resulting in body fat, but the mechanism is not clear. We intend to verify the correlation between shift work and obesity, to explore the way melatonin affects adipocyte proliferation by influencing the rhythms of clock genes and c-Myc in adipose tissue, using cosine software analysis and RNAi, from population, animals and cells. We clarify that obesity caused by shift work may be achieved through the melatonin-clock gene- fat synthesis related gene pathway. The project will find a new way to investigate the obesity in occupational groups and provide a theoretical basis of the health promotion for them.