仿生手性纳米硅具有螺旋形貌，多孔，结构精密可控，性质稳定，易于表面功能化修饰等性质，可精确控制药物释放，提高药效，降低毒性。课题从四方面进行研究,第一,将氨基酸衍生物类凝胶因子、手性表面活性剂等模板材料的电荷密度、偶极矩等结构参数和超分子特征与最小胶凝浓度、CMC性质关联，利用仿生手段，构建大小形状可控可调的手性纳米给药系统；第二，以手性纳米硅载体形貌、粒径、孔径、手性等为指标，结合结构信息，建立二者之间的关联，从分子结构层面分析异同的原因，发现手性纳米硅载体的形成机制及规律；第三，通过酒石酸、氨基酸衍生物等手性小分子对手性载体表面的二次手性修饰探究改善载体的手性识别能力的可能性；第四，深入研究手性纳米硅对模型药物的载药和释药特性，探索内在因素及规律；第五，以手性纳米硅与组织蛋白的结合能力，体内药动学及体内分布为主要研究内容探究材料的手性识别和体内转运机制，进行全面生物学评价。

Biomimetic synthesized chiral nano-silica possess several features, such as helical morphology, porous and controllable structure, stable charateristic, easy to realize surface modification, which rending it abilities to preciselycontrol drug release, improve drug efficiency and reduce toxicity. The project will be conducted from the following four aspects. Firstly, build up chiral nano-silica drug delivery system with adjustable sizeand morphology using biomimetic method based onscientific relationships between structure parameters (charge density, dipole moment etc.) and supermolecular characters with minimum gelation concentration and critical micelle concentration. Secondly, morphology, partical size, pore size and chirality are regarded as indexes to correlate with structure information of chiral nano-silica, further to analyse these differences at the molecular level in order to investigate formation mechanism and principles of chiral nano-silica. Thirdly, chirality of as-synthesized silica can be possibly improved with the second chirality modificationusing small chiral molecules like tartaric acid and amino acid derivativies. Fourthly, drug loading and relase of model drugs using chiral nano-silica as carries will be deeply investigated to explore initial parameters and principles. Lastly, systemic biological evaluation of chiral nano-silica will be developed by investigating chiral recognition and in vivo transport mechanisms with main research contents consisting of combining capacity between hiral nano-silica and histone, in vivo pharmacokinetics and distribution. .Keywords: chiral nano-silica; Biomimetic synthesis; drug release characteristics; chiral recognition, pharmaceutics.