申请人入选2012年度教育部新世纪优秀人才支持计划；主要从事食品复杂碳水化合物（主要为生物活性多糖与膳食纤维）、食品营养与安全等领域研究。主持或参与国家自然科学基金、863、973等13项国家级课题，迄今为止发表SCI期刊论文80余篇。主要学术成绩有：系统研究了黑灵芝多糖、车前子多糖等生物活性多糖的结构、功能及其构效关系，建立了较完整的生物活性多糖结构与功能研究体系，从分子与细胞水平初步揭示其活性作用机制。如有幸获得资助，将针对多糖体内作用机制不明确的问题开展生物活性多糖体内消化酵解与代谢途径研究，该工作将探明生物活性多糖在体内产生功效作用的物质基础与途径，可为探讨其体内可能作用机理提供系统的研究方法和模型，具有良好的原创性和学术前沿性。多糖研究已成为继蛋白质、核酸之后探索生命奥秘的第三个里程碑，本研究结果不仅可为多糖在体内的营养机制提供重要理论依据，也可为多糖生物学研究提供新的方法体系。

The applicant was selected into the Program for New Century Excellent Talents in University in 2012. The applicant’s research interests include food complex carbohydrates (including bioactive polysaccharides and dietary fiber), food nutrition and safety, etc., especially focused on developing novel polysaccharides and dietary fibre from natural agricultural products and exploring their applications in foods, medicinal and pharmaceutical industries, developing new methodology to determine new harmful chemicals that were produced during the heated process in food industries and study their formation mechanisms. .The applicant has chaired or participated in 13 national level' projects that were supported from the National Natural Science Foundation of China, the National High Technology Research and Development Program of China (863 Program) and the Major State Basic Research Development Program of China (973 Program), etc.. So far, the applicant had published over 80 papers on journals that included into the database of Science Citation Index Expanded (SCIE) (first or corresponding author for 36 papers). The main academic achievements of the applicant were as followed: the study systematically on the structure and biological activities of polysaccharides from Ganoderma atrum and the seeds of Plantago asiatica L. and discuss their structure-activity relationship. Established a relatively complete research system for the structures and biological activities of polysaccharides, and revealed their bioactive mechanisms from the molecular and cellular level..If I am enough lucky to get this project from the National Natural Science Foundation of China, I will focus on the study of digestion and fermentation in vivo of bioactive polysaccharides and explore their metabolic pathways in vivo, in order to explain the action mechanism in vivo of polysaccharides. This project will elucidate the material basis and pathway that bioactive polysaccharides make effects in vivo. This work will establish the scientific research system and model for exploring the possible action mechanism in vivo of bioactive polysaccharides, which should be original and creative academic research. The studies about polysaccharides have become the third milestone for exploring the mystery of life after the studies of protein and nucleic acid. The results of this project not only can provide the theoretical basis for the possible nutrition mechanism in vivo of bioactive polysaccharides, but also provide the new method systems and research models for glycobiology..

多糖（polysaccharide）是生物体内除蛋白质和核酸以外的又一类重要的生物大分子，多糖的研究已成为继蛋白质、核酸研究之后探索生命奥秘的第三个里程碑。目前国内外多糖研究的层次与水平，远远落后于蛋白质和核酸，主要反映在多糖的体内作用机制大多未知。因此，对于多糖的体内作用机制的研究已经成为了国内外多糖研究迫在眉睫的问题。本课题针对上述关键问题进行了系统研究，并归纳总结出了多糖进入人体消化道后的消化酵解与代谢途径：大分子生物活性多糖在人体胃肠道消化酵解前段（胃部和小肠段）并不会有太大的降解，而其主要的降解场所为消化酵解后段（大肠段，尤其结肠段）并依赖于人体大肠中的肠道菌群对多糖的分解利用及代谢，并得到不同生物活性多糖体内消化酵解与代谢途径的区别性。为初步探讨生物活性多糖在人体内可能的作用机理提供理论依据。该研究具有良好的原创性和学术前沿性，其研究结果可为多糖消化酵解与代谢途径及体内作用机制研究提供理论依据及研究模型。整体研究取得了一系列的原创性成果。在该方向上已经发表发表22篇SCI论文（20篇为资助第一标注；2篇为资助第二标注），4篇中文核心（均资助第一标注）；出版英文专著一部。授权6项国家专利；培养博硕士研究生10余名，项目相关成果获得6项重要奖项（省部级）。项目负责人入选2015年创新人才推进计划（中青年科技创新领军人才），2016年度获国务院政府特殊津贴。