营卫气化包括营卫离合交感、营卫相互转化，包含能量代谢过程，构成人体内环境稳态。营卫气化与代谢和微环境协作稳态是相通的，疏肝健脾以调和营卫，代表方丹栀逍遥散通过调节代谢与微环境之间的串扰干扰乳腺癌代谢重编程以逆转乳腺癌因营卫气化紊乱所致的进展。用丹栀逍遥散干预MDA-MB-231乳腺癌细胞裸鼠移植瘤，采用小动物超声和活体成像系统动态监测移植瘤发生发展过程，散斑扫描裸鼠瘤体及腹部微循环，代谢组学分析乳腺癌血液代谢物变化信息，运用免疫组化、ELISA、免疫印迹等技术观察肿瘤与骨髓组织糖酵解关键酶、缺氧标记、细胞外基质变化，探讨丹栀逍遥散对代谢和微环境协作稳态的影响；体外肿瘤相关成纤维细胞、骨髓间充质干细胞分别与乳腺癌细胞共培养，探讨丹栀逍遥散是否通过干预肿瘤、骨髓微环境影响乳腺癌细胞生长、进展，其作用机制是否与其旁分泌MIF蛋白及MIF/CXCR4、PI3K/AKT信号转导通路有关。

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