高效识别和衍生结构多样化的天然抗病毒活性分子，是抗病毒研究的重要方向之一。本项目主要基于前期工作基础和双方的研究优势上，法方主要承担大戟科抗病毒活性萜类衍生物及其作用机制的研究工作，抗病毒活性主要侧重于CHIKV病毒。中方主要承担大戟科叶下珠属植物中抗病毒倍半萜衍生物及其结构修饰、作用机制的研究工作。共同优化和构建大戟科抗病毒萜类成分快速分离的molecular networking新方法，并对前期发现具有抗病毒活性的主要倍半萜类衍生物进行结构修饰和衍生，开展抗HBV和CHIVK活性测试和其作用机制研究，以期发现高效低毒的抗病毒先导化合物。最重要的是以本项目为切入点，进一步加强中法合作，优势互补，加强我们研究团队在抗病毒先导分子的研究能力。

An important research strategy in antiviral discovery is to investigate the diverse active natural products by isolation and synthesis. The proposed research in this project will continue our investigation on antiviral terpenes in Euphorbiaceae family to yield the various terpenes with anti-HBV and CHIKV activities. Furthermore, structural modification will be done in the active site of the active molecules. Using molecular networking method, antiviral terpenes with the structural diversity in Euphorbiaceae family will be yield as soon as possible. Furthermore, the possible antiviral mechanisms of the active compounds will be investigated. Our goal is to identify a couple of antiviral lead compounds, laying a foundation for developing new and safer antiviral drugs.