消癌解毒方是基于中医肿瘤癌毒病机理论，通过辨治癌毒病机，进而配伍形成的抗肿瘤临床有效验方。前期研究表明消癌解毒方干预肿瘤微环境及炎性微环境发挥抗肿瘤作用，而炎癌转化机制与肿瘤微环境，特别是炎性微环境关系密切。我们研究认为，消癌解毒方可能通过调控炎癌转化网络防治肿瘤。本项目结合文献研究及前期实验基础，以癌毒病机理论为指导，通过体内及体外实验，化学分离分析与药理药效指标相结合，应用现代色谱波谱技术，结合系统生物学、分子生物学、细胞生物学、表观遗传学等手段，从宏观与微观，基于整体、细胞、分子基因等多层次，观察分析消癌解毒方、相关组分及部位、单体成分对结肠炎癌转化模型及其关键信号通路NF-κB、STAT3的影响，分析分离活性组分，重点辅以现代谱学串联技术，探讨复方调控炎癌转化的活性组分及分子机制，揭示复方配伍机理，为应用癌毒病机理论指导肿瘤防治以及抗肿瘤药物的创制提供依据。

Xiaoai jiedu recipe is an effective recipe prescribed for cancer treatment formed by compatibly combining herbals through treatment based on pathogenesis differentiation, directed by the “ai du” pathogenesis theory. Previous studies showed that xiaoai jiedu recipe played a key role in cancer treatment through intervening tumor and inflammatory microenvironments. The mechanism of inflammation-cancer transformation is closely associated with tumor microenvironment, especially with inflammatory microenvironment. Our study suggests that xiaoai jiedu recipe can prevent and treat cancer by regulating and controlling inflammation-cancer transformation network. This project aims to investigate the effects of xiaoai jiedu recipe, its related components and parts, and invidiual components on colon inflammation-cancer transformation model and key signaling pathways of NF-κB, STAT3, as well as to analyze and isolate active components, through in vivo and in vitro experiments, combination of chemical separation and analysis and pharmacological efficacy indicators, application of modern chromatographic spectrum technology, by means of systems biology, molecular biology, cell biology, epigenetics and the like, on macroscopic and microscopic levels of overall, cells, genes and molecules. With the aid of modern spectroscopy in series technology, we explored the active components regulating and controlling inflammation-cancer transformation in the recipe and molecular mechanism thereof, and reveal compatibility mechanism of the recipe, laying a foundation for prevention and treatment of cancer and formulation of anti-cancer drugs.