纳鼻通关是中医传统治法。如何将其与现代嗅区递药理论进行对接，传承与建立中医独特的纳鼻通关理论；解决中药纳鼻通关技术的共性问题，搭建具有中医传统纳鼻法研究与应用平台，成为传承这种古老的用药方法亟需解决的问题。.中医纳鼻通关与嗅区递药入脑理论殊途同归，在前期科技部重大新药创制研究基础上，以黄芩苷、栀子苷及胆酸为研究对象：与现代嗅区递药理论对接，多层次、多角度探寻药物纳鼻之“关”之所在；对通“关”时间及量进行考察。以增加中药纳鼻通关之“通”量为切入点：采用现代载药系统，增加纳鼻嗅区黏膜之“通”量；在沿袭传统纳鼻法的基础上制备现代纳鼻剂；以提高纳鼻通关之“通”脑量。从物理化学性质、PAMPA模型、嗅黏膜渗透机理、整体药动学实验及“效-剂-时”对应的PK-PD研究多角度研究“通”关机理。.本研究所得结果不仅可以系统揭示纳鼻通关机理，还助于拓宽现代纳鼻给药的范围，为现代纳鼻制剂的开发提供新的理论基础。

Treating disease by the "TongGuan" route is the traditional therapeutic method.How to inherit the extraordinary concept by explainning the " TongGuan " on the basis of the olfactory transferring theory and how to overcome the common problem and build the research and application platform of the the traditional medicinal therapy are the urgent problems which need to be solved..There is a connection between the traditional “TongGuan” theory and the contemporary olfactory-route study.On the basis of preliminary work which funded by Ministry of Science and Technology,our research group selected three active components,which are baicalin，geniposide and cholic acid as the objects of this study,we plan to investigate the delivery route of drug to explain the “Guan” theory and to explore the amount and time for passing by the “Guan”.Secondly,we focus on the study of “passing” theory:the drug carrier system will be applied to increase the bypassing the olfactory mucosa of the components；and the nasal preparation will be made to increase the components'concentration in the brain.The mechanism will be investigated by the physicochemical properties study, parallel artificial membrane permeability determination, permeation mechanism of olfactory mucosa and PK-PD research which is according to the"effect,preparation and time"..All the research above are expected to explain the " TongGuan " mechanism, broaden the application of modern intranasal administration and provide the new theory for the development of new preparations.