电离辐射可通过损伤或抑制包括树突状细胞（DC）在内的免疫细胞而引发机体免疫功能障碍，并继发感染。我们前期研究发现：由熟地、山茱萸、冬虫夏草等组成的补肾解毒方可以防治电离辐射引起的免疫损伤，并能激活TLR4信号通路，而后者在DC活化中发挥重要作用，故我们推测补肾解毒方通过激活TLR4受体促进DC活化，继而维持受辐射照射机体的免疫功能。因此本课题拟在前期研究基础上，通过流式细胞术、ELISA、PCR等实验技术和方法，系统评估补肾解毒方对受辐射小鼠免疫功能的保护作用，评价其对DC功能损伤的防治效应，并深入研究TLR4信号通路在补肾解毒方防治辐射诱导DC功能损伤中的作用，以期为辐射引发的免疫损伤提供防治结合的中药防护剂，并阐明其作用机理。

As a result of damaging or immune cell inhibition, including dendrite cells (DCs), ionizing radiation can induce immune dysfunctions and cause secondary infections. Our preliminary study indicates that Bushenjiedu prescription, consisting of traditional Chinese herbal medicine Shudi, Shanzhuyu, and Dongchongxiacao, can prevent the immunological injury caused by ionizing radiation and activate Toll-like receptor 4 (TLR4) signaling pathway, which plays an important role in the activation of DC. We propose that Bushenjiedu decoction could promote the activation of DC by TLR4 and maintain the immune function after irradiation. Following this hypothesis, this research is aimed to evaluate the protective effect of Bushenjiedu on the immune system, especially the DC dysfunction, in irradiated mice. Furthermore, we explore the role of TLR4 signaling pathway in the preventive effect of Bushenjiedu prescription on irradiation-induced DC dysfunction, therefore, by clarifying the potential mechanism, we provide a protective and therapeutic Chinese herbal agent for irradiation-induced immune injury.