慢性炎症与肿瘤发生发展密切相关，深入研究慢性炎症恶性转化的机制对于肿瘤的预防和早期诊断意义重大。我们前期研究发现多个microRNA 以及重要肿瘤相关基因相互调控是炎-癌发生基因调控网络的关键节点。本项目以探索具有普适性的炎-癌发生调控机制为研究目标，综合基因组学、生物信息学、分子生物学、细胞学和临床实验等多种手段，以期构建以 microRNAs 及重要肿瘤相关基因为关键节点的慢性炎症相关肿瘤调控网络，为药物研发寻找新的治疗靶点。在此基础上，以包括 miR-375 在内的关键节点 microRNAs 为研究对象，构建高通量的 microRNA 荧光报告小分子调节剂筛选系统，筛选潜在的抗肿瘤药物，并对候选小分子的抗肿瘤效果和成药性展开深入研究。这项工作将为慢性炎症相关肿瘤的预防、早期诊断和治疗提供全新的契机。

Chronic inflammation is tightly associated with cancer. Our previous work has identified many microRNAs and tumor-related genes, which are participated as crucial nodes in inflammation-cancer development regulatory networks. This project is aimed to reveal the universal regulatory mechanism of inflammation-cancer development. By the combination of genetics/bioinformatics/molecular biology/cell biology and clinical research, we hope to construct chronic-inflammation- associated cancer gene regulatory networks, especially focus on those crucial node microRNAs, thus to find some new targets for cancer therapy. Besides, the project will construct an efficient high throughput small molecule anticancer drugs screening system, which specifically targets the above key-node microRNAs including miR-375. By this system, we will screen our small molecule library, and further investigate the anti-tumor efficacy and mechanisms of candidate drugs. The project will provide novel chances for the prevention and early diagnosis and therapy of chronic-inflammation-associated cancers.