运气学说作为祖国医学基础理论重要组成部分，在五运六气禀赋与疾病易患性研究取得了很大进展，但运气禀赋在生物学和遗传学的微观机制研究尚未展开。基于科学假说：五运六气禀赋与疾病易患性相关是由于五运六气禀赋与疾病的基因多态性有关联。为了验证假说，本课题以NONFH为切入点，拟开展：1）30年回顾性病例研究，全面分析NONFH患者的运气禀赋（父母钤印、胎孕及出生禀赋），并且重点研究10种运气禀赋分型的差异性分布，找到NONFH是否存在易患性/阻患性的运气禀赋；2）前期完成NONFH易感基因多态性的循证筛选基础上，采用病例对照研究，进行7个易感基因多态性与10种运气禀赋的关联规则挖掘，找到两者的高频组合，为科学假说提供依据。本课题是对运气学说的科学实证和延伸应用，不仅对NONFH预防和治疗起到指导作用，而且对运气学说的传承和创新，发扬运气学在禀赋调控与遗传性疾病防治上的优势与特色, 均具有深远的意义。

Yunqi theory is an important part of Chinese medicine basic theory, the current research mainly focus on the relationship between Physical endowment of Wuyunliuqi and disease tendency. However, the biological and genetic micro-mechanism of Yunqi endowment has not yet known. Therefore, Our hypothesis: Yunqi endowment related to disease susceptibility is due to the strong correlation of Yunqi endowment and gene polymorphisms of disease susceptible patients. To verify the assumption: the NONFH was used as disease model, we intends to carry out: 1) A comprehensive analysis of NONFH with endowment (parents endowment, fetal endowment, birth endowment) by using 30 years retrospective case study, and mainly focus on the difference distribution of 10 kinds of endowment and find whether there is Yunqi endowment in NONFH; 2) Based on the previous screening of NONFH susceptible gene polymorphism, by using a case control study, the association rule mining was carried out to find out the high frequency combination of susceptible gene polymorphism and 10 kinds of Yunqi endowment. Our aim is to provide scientific evidence and extend the application of Yunqi theory, our result will not only instruct the prevention and treatment of NONFH , but also show profound significance in the regulation of Yunqi endowment and hereditary diseases prevention.