高血压作为一种严重危害人类健康的疾病，是我国乃至世界的重大公共卫生问题。因此，研究血压调控机制以实现对高血压的良好控制，具有重大的科学与社会意义。.本项目组在国际上首次发现调控血压的重要靶点—肾周脂肪组织，并在大鼠和实验猪中证实了减少肾周脂肪量可使增高的收缩压降低约15mmHg。在30例高血压患者中，应用功率超声一次性辐照肾周脂肪，患者血压在肾周脂肪体积没明显减少的情况下降到正常，最长随访12个月时，受试者血压保持正常，提示超声辐照可能通过改变肾周脂肪性质或功能产生降压作用，其作用机制需进一步明确。.本项目拟研制一套机械/热效应耦合输出功率超声设备，通过功率超声的发射精确控制和状态实时反馈，实现超声波精准调配机械/热效应。应用该系统研究肾周脂肪调控血压的精准机制，包括肾周脂肪内交感神经元细胞和脂肪细胞在血压调控中的作用，探寻与血压调控相关的声敏/热敏蛋白，开辟功率超声研究细胞功能的新领域。

Hypertension, a disease threatening human health seriously, has become a global public health problem. Therefore, it is of great scientific and social value to delve into the regulatory mechanism of blood pressure for better control of hypertension..In the prior studies, we have verified a target (peri-renal fat) for the regulation of blood pressure unprecedentedly. A series of experiments (the objects including rat, pig and human) have been performed to confirm that the elevated systolic blood pressure could be reduced about 15 mmHg with peri-renal fat removed partially in one time. The blood pressure of all 30 human subjects dropped to normal level in one month post-operationally and remained stable within the follow-up period (the maximum follow-up period is more than12 months). Yet the specific mechanism has not been well discovered..In the subsequent program, a novel power ultrasound system will be developed. With precise control of the incident ultrasound wave functions and real-time monitor of the acoustic energy delivery, the output of mechanical/thermal coupling effects can be finely adjusted. With the help of this system, we will systemically explore the impact of ultrasound-induced mechanical /thermal coupling effects on neurons and adipocytes, the mechanism of blood pressure change after peripheral fat modification, and the medium acoustics- or temperature-sensitive protein involved in relative mechanisms. This novel power ultrasound system will open more possibilities for the study of cell functions treated by power ultrasound.