宫腔粘连（IUA）是引起女性继发不孕的第二大病因，发病与子宫内膜损伤相关，目前国内外均无理想的预防及治疗方法；经血中含有干细胞（MenSCs），该干细胞可诱导分化为内膜细胞，且无创获得，有可能成为修复IUA损伤内膜的种子细胞；Ferumoxytol是FDA认证的临床用药，有良好的超顺磁性，若将MenSCs与Ferumoxytol复合物结合就有可能在活体状态下用磁共振（MR）对IUA内膜修复进行特异性的细胞成像；子宫内膜的蠕动可能与受孕相关，MR动态电影序列可监测，内膜蠕动的变化可能与IUA损伤、修复相关。本项目拟用Ferumoxytol为MR示踪剂，对以上假设进行实验，在细胞和分子水平观察IUA的发生、修复与转归，探讨MenSCs修复IUA损伤内膜的可行性及其作用机制；应用MR监测IUA治疗前后子宫内膜蠕动的变化并阐明其可能机制，为IUA的预防、细胞治疗及分子影像学示踪与评估提供实验基础。

Intrauterine adhesions (IUA) is the second-largest cause of secondary infertility in women. It occurs mostly as a result of trauma, particularly associated with the degree of endometrial damage. There aren’t ideal prevention and treatment methods on IUA by now; It has been confirmed by experiments that there are stem cells in menstrual blood (menstrual blood-derived mesenchymal stem cells, MenSCs). These cells can be induced to differentiate into endometrial cells and obtained noninvasively. MenSCs may play a functional role in the regeneration of endometrium.; Ferumoxytol is FDA-approved agent used for treatment of iron deficiency in patients with anemia. It provides a strong signal on MR images. The authous hypothesize that this clinically applicable iron oxide nanopartical compound can be used as a stem cell marker. It is possible to develop an immediately clinically applicable MRI test for in vivo tracking of Ferumoxytol-labeled MenSCs engraftment outcomes noninvasively on endometrial repair. Peristaltic endometrium may be associated with pregnancy and it can be monitored with MR dynamic movie sequences. The changes of endometrial peristalsis may be associated with endometrial damage and repair. Here the authous intend to use Ferumoxytol as molecular probe for MR tracking. We plan to explore the feasibility and potential mechanism of endometrial repair with MenSCs, and use MR imaging to follow-up endometrial peristalsis at different time points before and after transfusion of MenSCs. This study is to investigate the stem cells based theatment of IUA using MR cellular imaging in vivo noninvasively and dynamically. This novel molecular imaging method is possible to provide theory basis and experimental data for the prevention and repairment of IUA, which may provide new ideas and new ways to the cell therapy of IUA.