糖尿病周围神经痛（DPNP）是糖尿病周围神经病（DPN）的常见表现，防治困难，疼痛严重影响患者生活质量。DPNP发病机制目前尚不明确。此前有研究认为背根神经节（DRG）神经元离子通道活动改变及炎症反应增强在DPNP的发生发展中起重要作用。我们的前期研究发现常被用于治疗糖尿病血管并发症的活血化瘀中药丹红注射液的主要有效成分丹参素可以拮抗高糖培养状态下DRG神经元TRPV1和Nav1.8通道活动及降低TNF-α和IL-1促炎因子的表达。本研究拟进一步通过大鼠体内实验评价丹参素治疗DPNP的疗效，同时利用膜片钳及分子生物学技术对DPNP大鼠DRG神经元离子通道活动、炎症激活通路的变化以及丹参素对其的调控进行研究，进而阐明丹参素除作用于血管病变之外的治疗DPNP的新的神经治疗靶点，为临床应用活血化瘀中药治疗DPNP提供新的分子生物学依据。

Diabetic peripheral neuropathic pain(DPNP) is a common manifestation of diabetic peripheral neuropathy, which is hard to treat and prevent, and severely reduces patients’ quality of life(QoL). The underling mechanism of DPNP is not clear, altered function of ion channel in dorsal root ganglion(DRG) neurons and increased inflammatory level are thought to play important roles in development of DPNP. Our research team found that Tanshinol, main effective component of Danhong injection which is used for treatment of vascular complications of DPN, can antagonize the increased activity of TRPV1 and Nav1.8 and decrease the expression of inflammatory factors such as TNF-α and IL-1 in DRG neuron cultured in hyperglycemic condition. This research aims to evaluate the efficacy of Tanshinol on alleviating DPNP in animal model and to study the molecular pathways responsible for altered activity of ion channel and increased inflammation by Patch-clamp and Molecular Biochemistry techniques, moreover find out new molecular targets for treatment of DPNP of Tanshinol, besides the effects on vasculopathy. Our work can provide new molecular biological evidences for clinical application.