研究表明：睡眠节律扰乱影响极端环境从业人员认知功能，损害感觉门控功能（SG），并引起CLOCK基因表达的改变，但具体机制不明。动物实验显示CLOCK基因突变小鼠感觉门控功能下降，伴双向情感障碍类似行为异常。躁郁症患者CLOCK基因多态性与其情绪变化的频率增加及睡眠减少有关。提示调节CLOCK可能改善睡眠节律扰乱所致的门控功能受损，改善认知功能。我们前期发现睡眠节律扰乱所致的认知损害具有个体差异性。据此推测：CLOCK基因多态性与个体睡眠节律扰乱后感觉门控功能损害程度有关。本项目拟分析不同CLOCK基因表型个体在睡眠节律扰乱后，基因表达量变化及感觉门控功能变化的差异；在行为干预后，基因表达量变化及感觉门控功能变化的差异。在分子及认知神经功能水平深入研究不同基因表型引起不同认知功能损害的机制，为极端环境从业人员的选拔及干预提供依据。

Researches showed: disruption of sleep rhythm can cause obvious impairment on people’s cognitive function, who work under extreme environments. Their sensory gating (SG) function could be impaired, and expression of circadian genes would change, including CLOCK gene, but the mechanism is still unclear. Animal researches showed that sensory gating function of mice with mutation of CLOCK gene was worse than wild mice, and behaved like patients of bipolar disorder. Polymorphism in the CLOCK gene was linked with more frequent episodes of mood disturbances and reduced need for sleep. These researches suggest that SG impairment caused by sleep disruption can be improved by adjusting expression of CLOCK gene. And we found that degree of cognitive impairment caused by disruption of sleep rhythm differentiated greatly between different people.We conclude: polymorphism in CLOCK gene is correlated with degree of impairment of sensory gating function after disruption of sleep rhythm. In this study, we will compare the expression changes and sensory gating function changes between different CLOCK genotype, in conditions of disruption of sleep rhythm and behavioral intervene. And we hope to clarify the mechanism of cognition impairment at molecular and neural function level, and provide theoretical basis for personal selection and intervene under extreme environment.