申请者现为美国耶鲁大学Ira V. Hiscock教授， 公共卫生学院生物统计系主任。申请者在应用统计和生物信息领域有着二十多年的研究经验，在基因型转换建模、遗传流行病学、种群遗传学、复杂疾病基因定位、遗传风险预测、功能基因组学、蛋白质组学、基因通路分析、高维数据分析、网络分析以及药物开发等方面作出了很多贡献，共发表320余篇科学论文（总SCI引用次数达8348次），并应邀在数十所世界著名大学与国际会议上作过180余场邀请报告。申请者已主持二十多个美国国家卫生院、自然科学基金项目，并长期出任美国国家卫生院和自然科学基金基金评审委员会成员。申请者现任多个统计、遗传、生物信息权威期刊主编／编委。申请者是美国统计学会、国际数理统计、美国科学促进会选举会士，获得美国公共卫生学会颁给40岁以下最杰出卫生统计学家奖。申请者积极与国内大学进行合作，现担任北京大学长江讲座教授。

Dr. Hongyu Zhao is the Ira V. Hiscock Professor of Biostatistics and Professor of Statistics and Genetics, Chair of the Biostatistics Department, and the Co-Director of Graduate Studies of the Inter-Departmental Program in Computational Biology and Bioinformatics at Yale University. He received his B.S. in Probability and Statistics from Peking University in 1990 and Ph.D. in Statistics from the University of California at Berkeley in 1995. His research interests are the applications of statistical methods in molecular biology, genetics, drug developments, and personalized medicine. Some of his recent projects include large scale genome wide studies to identify genetic variants underlying complex diseases (Crohn’s disease, schizophrenia, bipolar, autism, and substance sbuse), biological network modeling and analysis, disease biomarker identification through proteomics, genome annotations for the 1000 Genomes Project, microbiome analysis, and systems biology study of herbal medicine. He has published over 320 articles (with SCI citation of 8348) in statistics, human genetics, bioinformatics, and proteomics, and edited two books on human genetics analysis and statistical genomics. He has trained over 70 doctoral and post-doctoral students, many of whom are holding tenured or tenure-track positions at major universities in the states and overseas. Dr. Zhao is a Co-Editor of Statistics in Biosciences, and serves on the editorial boards of several leading statistical and genetics journals. He was the recipient of the Mortimer Spiegelman Award for a top statistician in health statistics under the age of 40 awarded by the American Public Health Association. His research has also been recognized by the Evelyn Fix Memorial Medaland Citation by UC Berkeley, a Basil O'Connor Starter Scholar Award by the March of Dimes Foundation, election to the fellowship of the American Association for the Advancement of Science, the American Statistical Association, and the Institute of Mathematical Statistics. He has strong connection with Chinese universities, currently he serves as Changjiang visiting professor in Peking University.

本项目研究生物网络研究中的统计方法，开发新的统计工具进行描述生物学网络，理解复杂的基因调控关系和疾病异质性，从而为疾病诊断和药物发现提供帮助。在研究工作开展过程中，加强项目负责人之间的合作。具体来说，我们从四个方面开展研究：(1) 开发基于核可加模型的网络结构推断方法；(2). 发展进行数据融合和疾病异质性分析的统计方法和相关理论；(3) 发展估计网络动力学参数和预测网络动力行为的统计模型；(4) 基于网络信息的疾病诊断和治疗。发表SCI论文6篇，其中标注论文3篇，未标注论文3篇。已经接收但未发表论文2篇；还有三篇论文正在投稿过程中。同时，项目支持2位研究生到美国耶鲁大学各进行了为期三个月的学术访问，项目两负责人联合指导3名博士研究生，其中2名研究生已经毕业，一名在读。