中文摘要
以老年性聋模型鼠C57BL/6J为动物模型，以SIRT2及FOXO3a信号传导网络为枢纽，通过电生理、组织形态学、Western blotting等方法，观察复聪片对SIRT2的影响及其对FOXO3a信号通路下游的调控，探讨复聪片延缓C57BL/6J小鼠听力下降的分子机理，为老年性耳聋的防治提供新的治疗靶点。
英文摘要
The study will investigate the effect of FuCong Tablet on SIRT2 levels ,and whether SIRT2 will further affect the FOXO3a downstream pathways in the auditory neuropathway in C57BL/6J mice by western blotting、immunoprecipitated technology, To explore the molecular mechnism of FuCong Tablet preventing age-related hearing loss,and provide a potential therapeutic target of age-related hearing loss .