寨卡、埃博拉和流感等新发突发病毒性传染病已成为威胁公共卫生安全的严重隐患。申请人通过整合结构生物学、细胞生物学等研究方法，对流感和埃博拉病毒等重要病毒性传染病病原的侵入过程进行了深入研究，取得了一系列重要进展。目前已在国际学术期刊发表SCI论文39篇，其中以第一或通讯作者（含共第一或共通讯）在Cell，Science，Nature Reviews Microbiology等国际杂志发表论文10篇，这些工作均在国内完成；主持国家自然科学基金项目1 项，主持国家973项目子课题1项。病毒感染宿主细胞主要有三个步骤，入侵、复制、释放；申请人下一步拟将病毒“表面”入侵研究工作扩展到“内部”复制机理。以寨卡、埃博拉和流感等新发突发病毒聚合酶及其病毒复制相关蛋白的功能和结构特征为切入点，系统性地研究病毒在宿主细胞内部的复制过程，为有效防控新发突发病毒跨种间感染事件提供理论基础并指导药物靶点发现。

Emerging infectious diseases, including Zika virus, Ebola virus and influenza virus, have raised great public health concern worldwide. The applicant combined the structural biology, biochemistry and the cellular biology methods to study the mechanisms of virus entry, and mainly focused on the influenza virus and Ebola virus. These research activities enabled the applicant to publish, thus far, 39 peer-reviewed papers in international journals. Of these publications, he was the first or corresponding author in 10 papers, including two publications in Science, one publication in Cell and Nature Reviews Microbiology, respectively. He also has 2 grants from the National Natural Science Foundation of China and the China Ministry of Science and Technology National 973 project, respectively. Virus infection includes three key steps, entry, replication and release. In the current proposal, he plan to further extend his study from virus “Surface” entry mechanism to “Internal” replication mechanism. The structures and functions of polymerases and other replication-associated proteins from Zika virus, Ebola virus and influenza virus will be systematically studied, clearly demonstrating the replication process. The goal is to gain a comprehensive view on the interspecies transmission mechanisms and the replicative features of emerging infectious viruses, which would be valuable in counteracting the virus infections and providing guidance for therapeutics development.